INT94291

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Context Info
Confidence 0.40
First Reported 2001
Last Reported 2007
Negated 2
Speculated 1
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 3.05
Pain Relevance 3.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk3) mitochondrion (Mapk3) Golgi apparatus (Mapk3)
protein complex assembly (Mapk3) protein complex (Mapk3) cytoplasm (Mapk3)
Anatomy Link Frequency
hippocampus 4
spinal 2
gastrocnemius 2
Pa5 2
spinal cord dorsal horn 2
Mapk3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 38 99.40 Very High Very High Very High
Spinal cord 115 99.28 Very High Very High Very High
Hippocampus 102 99.04 Very High Very High Very High
qutenza 10 98.92 Very High Very High Very High
Lasting pain 56 98.28 Very High Very High Very High
Pain 157 97.32 Very High Very High Very High
depression 12 96.88 Very High Very High Very High
painful pain 8 96.88 Very High Very High Very High
Hyperalgesia 24 90.40 High High
anesthesia 1 89.60 High High
Disease Link Frequency Relevance Heat
Pain 216 98.28 Very High Very High Very High
Depression 14 96.88 Very High Very High Very High
Nervous System Injury 4 95.48 Very High Very High Very High
Hyperinsulinism 1 93.48 High High
Peripheral Arterial Disease 1 91.36 High High
Hyperalgesia 26 90.40 High High
Stress 20 76.44 Quite High
INFLAMMATION 21 75.48 Quite High
Neuropathic Pain 2 75.28 Quite High
Injury 4 70.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, the aim of the present series of experiments is to assess the spatial- and temporal-related changes in phosphorylation (activation) and protein expression of ERKs, mainly ERK1 and ERK2, in the spinal cord dorsal horn, SI area and hippocampus under both physiological pain (transient pain) and pathological pain (persistent pain) states.
Regulation (changes) of Gene_expression (expression) of ERK1 in spinal cord dorsal horn associated with pain, lasting pain, dorsal horn, painful pain, hippocampus and spinal cord
1) Confidence 0.40 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 1.64 Pain Relevance 1.61
L of CFA (data not shown); however, changes in the regulation of either spinal or hippocampal p-ERK levels were not observed at this time point either.
Regulation (regulation) of Gene_expression (levels) of p-ERK in spinal
2) Confidence 0.27 Published 2007 Journal Mol Pain Section Body Doc Link PMC2174921 Disease Relevance 0.25 Pain Relevance 0.36
Western blot analysis showed that 24 h or 21 days after CFA administration, p-ERK levels were generally not altered in either the dorsal horn or the hippocampus, except for slight increases in spinal p-ERK2 (Fig. 4).
Neg (except) Regulation (altered) of Gene_expression (levels) of p-ERK in hippocampus associated with dorsal horn and hippocampus
3) Confidence 0.27 Published 2007 Journal Mol Pain Section Body Doc Link PMC2174921 Disease Relevance 0.53 Pain Relevance 0.63
There were no significant changes in total expression levels of ERK1 or ERK2 in ipsilateral hippocampus at any time point examined (data not shown).
Neg (no) Spec (examined) Regulation (changes) of Gene_expression (expression) of ERK1 in hippocampus associated with hippocampus
4) Confidence 0.24 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.29 Pain Relevance 0.47
The pERK expression in the Vi/Vc zone and Pa5 was bilateral, whereas it was predominantly ipsilateral in the caudal Vc/C2 zone.
Regulation (bilateral) of Gene_expression (expression) of pERK in Pa5
5) Confidence 0.15 Published 2006 Journal Brain Res. Section Abstract Doc Link 16442086 Disease Relevance 0.25 Pain Relevance 0.64
To determine the relative contributions of glucose transport/hexokinase, glycogen synthase (GSase), and glycolysis to the control of insulin-stimulated muscle glycogen synthesis, we combined 13C and 31P NMR to quantitate the glycogen synthesis rate and glucose 6-phosphate (G-6-P) levels in rat (Sprague-Dawley) gastrocnemius muscle during hyperinsulinemia at euglycemic (E) and hyperglycemic (H) glucose concentrations under thiopental anesthesia.
Regulation (control) of Gene_expression (synthesis) of insulin-stimulated in gastrocnemius associated with anesthesia and hyperinsulinism
6) Confidence 0.10 Published 2001 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 11254467 Disease Relevance 0.09 Pain Relevance 0.09

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