INT94300

From wiki-pain
Revision as of 14:15, 24 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.79
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mbp) nucleus (Mbp) cytoplasm (Mbp)
Anatomy Link Frequency
brains 4
striatum 3
eosinophil 2
cortex 1
Mbp (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 49 100.00 Very High Very High Very High
unmyelinated 1 96.00 Very High Very High Very High
Neuritis 4 95.88 Very High Very High Very High
Spinal cord 9 87.92 High High
anesthesia 1 81.36 Quite High
Eae 16 79.00 Quite High
cytokine 24 74.96 Quite High
Abeta 4 50.00 Quite Low
sodium channel 39 48.76 Quite Low
Inflammation 18 23.80 Low Low
Disease Link Frequency Relevance Heat
Neuritis 4 95.88 Very High Very High Very High
Hypoxia 5 93.60 High High
Death 85 92.16 High High
Injury 14 91.92 High High
Urological Neuroanatomy 12 91.04 High High
Adhesions 24 90.32 High High
Cognitive Disorder 52 79.00 Quite High
Brain Hemorrhage 1 72.76 Quite High
Rhinitis 11 59.72 Quite High
Apoptosis 87 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression levels of MBP were decreased in the cortex, striatum axonal bundles and corpus callosum of A?
Negative_regulation (decreased) of Gene_expression (Expression) of MBP in striatum
1) Confidence 0.44 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.11 Pain Relevance 0
However, Western blotting showed that the levels of the myelin proteins myelin-associated glycoprotein (MAG) and myelin basic protein (MBP) in the CNS of the mutant at P6 were reduced compared with wild-type tissue and that they were similar to those observed at P4 in the wild-type (Fig. 2 B).
Negative_regulation (reduced) of Gene_expression (levels) of MBP associated with central nervous system
2) Confidence 0.42 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2442198 Disease Relevance 0.09 Pain Relevance 0.28
Following the memory retention test, the levels of P-NF-H, MAP2, synaptophysin and myelin basic protein (MBP, a myelin marker) were measured in the brains of the mice by immunohistochemistry.
Negative_regulation (measured) of Gene_expression (levels) of MBP in brains
3) Confidence 0.32 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.27 Pain Relevance 0.14
Following the memory retention test, the levels of P-NF-H, MAP2, synaptophysin and myelin basic protein (MBP, a myelin marker) were measured in the brains of the mice by immunohistochemistry.
Negative_regulation (measured) of Gene_expression (levels) of myelin basic protein in brains
4) Confidence 0.32 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.27 Pain Relevance 0.14
Using an in situ hybridization technique that gives high resolution and is very sensitive, we examined myelin basic protein and proteolipid protein gene expression three and twenty-four hours after a H-I insult.
Spec (examined) Negative_regulation (examined) of Gene_expression (expression) of myelin basic protein
5) Confidence 0.28 Published 2001 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 11255033 Disease Relevance 0.89 Pain Relevance 0.08
Expression levels of MBP were decreased in the cortex, striatum axonal bundles and corpus callosum of A?
Negative_regulation (decreased) of in cortex Gene_expression (Expression) of MBP in striatum
6) Confidence 0.15 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.11 Pain Relevance 0
In addition, high levels of PU.1 lead to an increase in myeloid differentiation.3 In most cells, PU.1 antagonizes GATA-1 (a zinc finger family member), the latter of which has synergistic activity in regulating eosinophil lineage specification and eosinophil granule protein transcription.4 The interferon consensus sequence binding protein (ICSBP) is also a key transcription factor for eosinophils and is demonstrated by a loss of eosinophils in ICSBP-deficient mice.5 Of these transcription factors, GATA-1 is clearly the most important for eosinophil lineage specification, based on loss of the eosinophil lineage in mice harboring a targeted deletion of the high affinity GATA-binding site in the GATA-1 promoter,6 and based on eosinophil differentiation experiments in vitro.7
Negative_regulation (loss) of Gene_expression (mice.5) of ICSBP-deficient in eosinophil
7) Confidence 0.14 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 0.06 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox