INT9433

Context Info Confidence 0.29 First Reported 1992 Last Reported 1992 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 3 Disease Relevance 2.38 Pain Relevance 1.19

cytoskeleton (Pfn2) cytoskeleton organization (Pfn2) cytoplasm (Pfn2)

Anatomy Link Frequency liver 1 spleen 1 Pfn2 (Mus musculus)

Pain Link Frequency Relevance Heat depression 12 99.64 ischemia 24 98.12 anesthesia 6 62.64

Disease Link Frequency Relevance Heat Depression 12 99.64 Reperfusion Injury 6 98.58 Cv General 4 Under Development 12 98.12 Cv Unclassified Under Development 12 89.48 Injury 6 83.04 Intraoperative Complications 3 43.00 Disseminated Intravascular Coagulation 3 41.68 Soft Tissue Injuries 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

RE depression was not due to a deficiency of pFn; indeed, a marked elevation (588 +/- 12 micrograms/mL versus 1,083 +/- 40 micrograms/mL) of pFn was observed by immunoassay over the 18-hour reperfusion interval.

Negative_regulation (deficiency) of pFn associated with depression

1) Confidence 0.29 Published 1992 Journal Am. J. Surg. Section Abstract Doc Link 1415924 Disease Relevance 0.79 Pain Relevance 0.45

Thus, the impaired liver and spleen clearance mechanism after peripheral ischemia and reperfusion injury did not appear to be due to either a macrophage cellular deficit or a lack of pFn.

Negative_regulation (lack) of pFn in liver associated with reperfusion injury, cv general 4 under development and ischemia

2) Confidence 0.29 Published 1992 Journal Am. J. Surg. Section Abstract Doc Link 1415924 Disease Relevance 0.80 Pain Relevance 0.37

Thus, the impaired liver and spleen clearance mechanism after peripheral ischemia and reperfusion injury did not appear to be due to either a macrophage cellular deficit or a lack of pFn.

Negative_regulation (lack) of pFn in spleen associated with reperfusion injury, cv general 4 under development and ischemia

3) Confidence 0.10 Published 1992 Journal Am. J. Surg. Section Abstract Doc Link 1415924 Disease Relevance 0.80 Pain Relevance 0.37

General Comments

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