INT94408

Context Info Confidence 0.65 First Reported 2001 Last Reported 2010 Negated 1 Speculated 2 Reported most in Body Documents 28 Total Number 30 Disease Relevance 12.89 Pain Relevance 3.53

mitochondrion (IFI27) molecular_function (IFI27)

Anatomy Link Frequency muscle cells 6 lungs 4 muscle 3 spinal cord 2 colon 2 IFI27 (Homo sapiens)

Pain Link Frequency Relevance Heat psoriasis 17 100.00 cINOD 50 99.98 dexamethasone 5 99.98 Spinal cord 70 99.20 aspirin 13 98.80 peptic ulcer disease 1 96.00 Inward rectifier potassium channel 2 93.64 Etanercept 1 93.20 Adalimumab 1 92.72 Infliximab 1 92.24

Disease Link Frequency Relevance Heat Psoriasis 23 100.00 Apoptosis 122 99.96 Gastritis 3 99.92 INFLAMMATION 43 99.88 Infection 22 99.48 Hypertrophy 100 99.34 Adenocarcinoma 54 99.12 Cancer 370 98.88 Pulmonary Sarcoidosis 6 98.76 Lung Cancer 141 97.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Also anomalous overexpression of p27 in human pancreatic endocrine tumors were reported [25].

Positive_regulation (overexpression) of Gene_expression (overexpression) of p27 associated with cancer

1) Confidence 0.65 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 1.29 Pain Relevance 0

Cells that had either weak or strong nuclear staining were considered to be positive for p27 protein expression.

Positive_regulation (positive) of Gene_expression (expression) of p27

2) Confidence 0.65 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 0.39 Pain Relevance 0

At present, we are not able to determine if in asymptomatic postmenopausal women the p27 expression in levator ani muscles also increases with age, since non-urogynecological surgery, except cancer (excluded), is exceptional in such cases.

Positive_regulation (increases) of in muscles Gene_expression (expression) of p27 in levator ani associated with cancer

3) Confidence 0.65 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0.30 Pain Relevance 0

Further increase in cytoplasmic staining (p27 overexpression) accompanies shrinking and fragmentation of muscle fibers.

Positive_regulation (overexpression) of Gene_expression (overexpression) of p27 in muscle fibers

4) Confidence 0.65 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0.17 Pain Relevance 0

An important question is whether the increase in cytoplasmic p27 expression correlates with the age of the patients and the severity of the muscle abnormality.

Spec (whether) Positive_regulation (increase) of Gene_expression (expression) of p27 in muscle

5) Confidence 0.65 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0.36 Pain Relevance 0

Mechanisms underlying nonsteroidal anti-inflammatory drug-induced p27(Kip1) expression.

Positive_regulation (induced) of Gene_expression (expression) of p27 associated with inflammation and cinod

6) Confidence 0.65 Published 2002 Journal Mol. Pharmacol. Section Title Doc Link 12435820 Disease Relevance 0.29 Pain Relevance 0.73

The percentage of cells expressing p27 was recorded as the ratio of positive cells-to-the total number of cells counted. p27 expression was grouped as high or low.

Positive_regulation (grouped) of Gene_expression (expression) of p27

7) Confidence 0.47 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 0.39 Pain Relevance 0

Patients with low p27 expression had less than 30% of the nuclei in the specimen staining positive, while those with high levels of p27 expression had more than 30% of the nuclei staining for the bound antibody [15].

Positive_regulation (levels) of Gene_expression (expression) of p27

8) Confidence 0.47 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 0.47 Pain Relevance 0

Fig. 10, panel A, shows that the mature CL of the menstrual cycle has p27 expression limited to the luteal vessels; luteal cells show only traces of nuclear p27 (arrow) and no cytoplasmic staining.

Positive_regulation (has) of in luteal cells Gene_expression (expression) of p27 in vessels

9) Confidence 0.47 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0.07 Pain Relevance 0

Conversely, levator ani from younger symptomatic patient (age 38) exhibited hypertrophy of muscle cells, accompanied by increased cytoplasmic p27 expression and manifestation of PFD.

Positive_regulation (increased) of Gene_expression (expression) of p27 in muscle cells associated with hypertrophy

10) Confidence 0.47 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0.47 Pain Relevance 0

RESULTS: Darbufelone inhibited the proliferation of non-small cell lung cancer cell lines in a dose-dependent manner, and induced cell cycle arrest at G0/G1 phase through up-regulation of p27 expression.

Positive_regulation (regulation) of Gene_expression (expression) of p27 in lung

11) Confidence 0.47 Published 2010 Journal Cancer Chemother. Pharmacol. Section Body Doc Link 20352217 Disease Relevance 0.16 Pain Relevance 0

Our previous study has shown, that differentiation of cells in tissue culture is associated with an increase in p27 expression [18].

Positive_regulation (increase) of Gene_expression (expression) of p27

12) Confidence 0.43 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0.33 Pain Relevance 0

Pelvic floor disorders in perimenopausal patients are associated with the hypertrophy of muscle cells and moderate cytoplasmic p27 expression, while PFD during advanced postmenopause are associated with shrinking and fragmentation of muscle cells and cytoplasmic p27 overexpression.

Positive_regulation (overexpression) of Gene_expression (overexpression) of p27 in muscle cells associated with hypertrophy and stress incontinence

13) Confidence 0.43 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0.36 Pain Relevance 0

Moreover, a combined action of estrogens and progesterone, characteristic for the luteal phase, appears to cause a diminution of nuclear p27 expression in the epithelium of ectocervix and endometrium (Fig. 9, C and 9F).

Spec (appears) Positive_regulation (cause) of Gene_expression (expression) of p27 in epithelium

14) Confidence 0.43 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0 Pain Relevance 0

Older symptomatic patients (ages 57–74) showed cytoplasmic p27 overexpression accompanied by shrinking, cytoplasmic vacuolization and fragmentation of muscle cells.

Positive_regulation (overexpression) of Gene_expression (overexpression) of p27 in muscle cells

15) Confidence 0.43 Published 2001 Journal BMC Clin Pathol Section Abstract Doc Link PMC59662 Disease Relevance 0.68 Pain Relevance 0

Although a regular p27 expression protects normal cells from apoptosis, overexpression of p27 induces apoptosis of cells, through elevation of proapoptotic proteins, such as Bax [19,20].

Positive_regulation (overexpression) of Gene_expression (overexpression) of p27 associated with apoptosis

16) Confidence 0.43 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0.50 Pain Relevance 0

We further found that indomethacin, celecoxib and dexamethasone increased the mRNA and protein expressions of p27(kip1) and decreased those of cyclin D2 and p-cdk2 in hOBs.

Positive_regulation (increased) of Gene_expression (expressions) of p27 associated with dexamethasone

17) Confidence 0.38 Published 2009 Journal Toxicology Section Abstract Doc Link 19428934 Disease Relevance 0.98 Pain Relevance 1.10

The finding was associated to increased levels of some CDKIs, namely p27(Kip1) and p21(Cip1), whereas ASA did not affected p16(Ink4A) level at any of the concentrations employed.

Positive_regulation (increased) of Gene_expression (levels) of p27 associated with aspirin

18) Confidence 0.38 Published 2008 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 19144277 Disease Relevance 0.13 Pain Relevance 0.51

There was no overexpression of p27.

Neg (no) Positive_regulation (overexpression) of Neg (no) Gene_expression (overexpression) of p27

19) Confidence 0.38 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2913917 Disease Relevance 0.41 Pain Relevance 0

It has also been reported that the expression of pso p27, a psoriatic scale antigen linked to the pathogenesis of psoriasis, is markedly increased in the lungs of patients with pulmonary sarcoidosis [16].

Positive_regulation (increased) of Gene_expression (expression) of p27 in lungs associated with pulmonary sarcoidosis and psoriasis

20) Confidence 0.35 Published 2006 Journal BMC Pulm Med Section Body Doc Link PMC1716762 Disease Relevance 2.12 Pain Relevance 0.57

General Comments

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