INT94490

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Context Info
Confidence 0.33
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.97
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6, Avp) extracellular region (Il6, Avp) signal transduction (Avp)
aging (Il6) response to stress (Avp) signal transducer activity (Avp)
Anatomy Link Frequency
hypothalamus 4
Il6 (Rattus norvegicus)
Avp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 28 100.00 Very High Very High Very High
cytokine 2 99.16 Very High Very High Very High
corticosteroid 12 92.00 High High
Arthritis 2 59.76 Quite High
rheumatoid arthritis 6 38.88 Quite Low
Inflammatory stimuli 2 32.64 Quite Low
Inflammatory response 2 25.00 Low Low
spinal inflammation 2 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 30 100.00 Very High Very High Very High
Necrosis 2 100.00 Very High Very High Very High
Cancer 2 100.00 Very High Very High Very High
Stress 2 75.00 Quite High
Arthritis 2 59.76 Quite High
Rheumatoid Arthritis 6 38.88 Quite Low
Disease 2 25.00 Low Low
Low Back Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pro-inflammatory cytokines, such as interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF alpha), released from inflammatory foci, can activate the hypothalamus to produce corticotrophin-releasing hormone (CRH) and arginine vasopressin (AVP).
IL-6 Positive_regulation (activate) of Gene_expression (produce) of AVP in hypothalamus associated with necrosis, inflammation, cancer and cytokine
1) Confidence 0.33 Published 2000 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 11268412 Disease Relevance 0.98 Pain Relevance 0.57
Pro-inflammatory cytokines, such as interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF alpha), released from inflammatory foci, can activate the hypothalamus to produce corticotrophin-releasing hormone (CRH) and arginine vasopressin (AVP).
interleukin-6 Positive_regulation (activate) of Gene_expression (produce) of AVP in hypothalamus associated with necrosis, inflammation, cancer and cytokine
2) Confidence 0.33 Published 2000 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 11268412 Disease Relevance 0.98 Pain Relevance 0.57

General Comments

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