INT94623

Context Info Confidence 0.62 First Reported 2001 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.17 Pain Relevance 2.94

cell differentiation (ADAM18)

Anatomy Link Frequency neuronal 1 ADAM18 (Homo sapiens) ADAM18 - L858F (1)

Pain Link Frequency Relevance Heat Nav1.7 98 99.90 qutenza 13 99.84 Pain 25 97.08 Pain threshold 1 95.92 addiction 6 92.44 peripheral neuropathy 1 55.64 Quantitative sensory testing 1 50.56 sodium channel 10 50.00 dorsal root ganglion 10 5.00 nav1.8 4 5.00

Disease Link Frequency Relevance Heat Pain 26 97.08 Neuropathic Pain 2 68.64 Peripheral Neuropathy 1 55.64 Erythermalgia 27 50.00 Ganglion Cysts 12 5.00 Complex Regional Pain Syndromes 2 5.00 Nociception 2 5.00 Disease 2 5.00 Increased Venous Pressure Under Development 2 5.00 Myotonic Disorders 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Skin biopsies were obtained and were processed for immunohistochemical localization of (ENFs) using the pan neuronal marker protein gene product 9.5.

Localization (localization) of neuronal marker protein gene product 9.5 in neuronal

1) Confidence 0.62 Published 2001 Journal Pain Section Abstract Doc Link 11275380 Disease Relevance 1.17 Pain Relevance 2.00

Thus for both WT and L858F, the sensitivity of the channels to small voltage changes close to the midpoint of activation is decreased at low temperatures.

Localization (decreased) of L858F (L858F) associated with nav1.7

2) Confidence 0.00 Published 2007 Journal Mol Pain Section Body Doc Link PMC1781932 Disease Relevance 0 Pain Relevance 0.94

General Comments

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