INT94647

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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Disease Relevance
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 3.84796
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 3.85
 
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Pain Relevance
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 2.90776
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 2.73
 
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| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[cINOD]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[cINOD]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 35
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 35
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 100
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 100.00
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
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| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Inflammation]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Inflammation]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 97.4
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 97.40
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
|-
 
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| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[COX2]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[COX2]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 6
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 6
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 25
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 25.00
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Low}} {{#icon: cold.png|Low}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Low}} {{#icon: cold.png|Low}}
 
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| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[cytokine]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[cytokine]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 3
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 3
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 25
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 25.00
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Low}} {{#icon: cold.png|Low}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Low}} {{#icon: cold.png|Low}}
 
|-
 
|-
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[COX-2 inhibitor]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[COX-2 inhibitor]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 25
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 25.00
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Low}} {{#icon: cold.png|Low}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Low}} {{#icon: cold.png|Low}}
 
|-
 
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| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[cOX1]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[cOX1]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 2
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 2
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 25
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 25.00
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Low}} {{#icon: cold.png|Low}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Low}} {{#icon: cold.png|Low}}
 
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{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| <span style="background-color:#FFFF00">NSAIDs</span> <span style="background-color:#B0E0E6">inhibit</span> cyclooxygenase (<span style="background-color:#FFFF00">COX</span>)-1 and/or COX-2 activity, but the chemopreventive effect may be, in part, independent of prostaglandin inhibition.  
+
| <span style="background-color:#FFA07A">NSAIDs</span> <span style="background-color:#B0E0E6">inhibit</span> cyclooxygenase (<span style="background-color:#FFFF00">COX</span>)-1 and/or COX-2 activity, but the chemopreventive effect may be, in part, independent of prostaglandin inhibition.  
 
|-
 
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|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''NSAIDs'''</span> <span style="color:#000080">'''Negative_regulation'''</span> (<span style="color:#000080">inhibit</span>) of <span style="color:#800000">'''COX'''</span>
+
| <span style="color:#800000">'''NSAIDs'''</span> <span style="color:#000080">'''Negative_regulation'''</span> (<span style="color:#000080">inhibit</span>) of <span style="color:#800000">'''COX'''</span> associated with <span style="color:#FF0000">'''cinod'''</span>
 
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=12023546 12023546]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=12023546 12023546]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.46
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.87
 
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|}
 
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{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''NSAIDs'''</span> <span style="color:#000080">'''Negative_regulation'''</span> (<span style="color:#000080">inhibit</span>) of <span style="color:#800000">'''COX'''</span>
+
| <span style="color:#800000">'''NSAIDs'''</span> <span style="color:#000080">'''Negative_regulation'''</span> (<span style="color:#000080">inhibit</span>) of <span style="color:#800000">'''COX'''</span> associated with <span style="color:#FF0000">'''cinod'''</span>
 
|-
 
|-
 
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=15102586 15102586]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=15102586 15102586]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.52
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.36
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| <span style="background-color:#FFFF00">NSAIDs</span> <span style="background-color:#B0E0E6">inhibit</span> cyclooxygenase (<span style="background-color:#FFFF00">COX</span>), which has subtypes COX-1 and COX-2.  
+
| <span style="background-color:#FFA07A">NSAIDs</span> <span style="background-color:#B0E0E6">inhibit</span> cyclooxygenase (<span style="background-color:#FFFF00">COX</span>), which has subtypes COX-1 and COX-2.  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''NSAIDs'''</span> <span style="color:#000080">'''Negative_regulation'''</span> (<span style="color:#000080">inhibit</span>) of <span style="color:#800000">'''COX'''</span>
+
| <span style="color:#800000">'''NSAIDs'''</span> <span style="color:#000080">'''Negative_regulation'''</span> (<span style="color:#000080">inhibit</span>) of <span style="color:#800000">'''COX'''</span> associated with <span style="color:#FF0000">'''cinod'''</span>
 
|-
 
|-
 
|}
 
|}
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=19101538 19101538]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=19101538 19101538]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.66
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.66
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| <span style="background-color:#FFFF00">NSAIDs</span> <span style="background-color:#B0E0E6">inhibit</span> cyclooxygenase (<span style="background-color:#FFFF00">COX</span>), of which two isoforms exist.  
+
| <span style="background-color:#FFA07A">NSAIDs</span> <span style="background-color:#B0E0E6">inhibit</span> cyclooxygenase (<span style="background-color:#FFFF00">COX</span>), of which two isoforms exist.  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''NSAIDs'''</span> <span style="color:#000080">'''Negative_regulation'''</span> (<span style="color:#000080">inhibit</span>) of <span style="color:#800000">'''COX'''</span>
+
| <span style="color:#800000">'''NSAIDs'''</span> <span style="color:#000080">'''Negative_regulation'''</span> (<span style="color:#000080">inhibit</span>) of <span style="color:#800000">'''COX'''</span> associated with <span style="color:#FF0000">'''cinod'''</span>
 
|-
 
|-
 
|}
 
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=11754989 11754989]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=11754989 11754989]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.74
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.30
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| <span style="background-color:#B0E0E6">Blockade</span> of <span style="background-color:#FFFF00">COX enzyme</span> by <span style="background-color:#FFFF00">NSAIDs</span> down-regulates its metabolic product prostaglandin E2.  
+
| <span style="background-color:#B0E0E6">Blockade</span> of <span style="background-color:#FFFF00">COX enzyme</span> by <span style="background-color:#FFA07A">NSAIDs</span> down-regulates its metabolic product prostaglandin E2.  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''NSAIDs'''</span> <span style="color:#000080">'''Negative_regulation'''</span> (<span style="color:#000080">Blockade</span>) of <span style="color:#800000">'''COX enzyme'''</span>
+
| <span style="color:#800000">'''NSAIDs'''</span> <span style="color:#000080">'''Negative_regulation'''</span> (<span style="color:#000080">Blockade</span>) of <span style="color:#800000">'''COX enzyme'''</span> associated with <span style="color:#FF0000">'''cinod'''</span>
 
|-
 
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=18019697 18019697]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=18019697 18019697]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.52
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.26
 
|}
 
|}
 
|-
 
|-
 
|}
 
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{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| Although the exact mechanisms remain unclear, the <span style="background-color:#B0E0E6">inhibition</span> of cyclooxygenase (<span style="background-color:#FFFF00">COX</span>) by <span style="background-color:#FFFF00">NSAIDs</span> appears to abort, if not prevent, CRC carcinogenesis or metastatic tumor progression.  
+
| Although the exact mechanisms remain unclear, the <span style="background-color:#B0E0E6">inhibition</span> of cyclooxygenase (<span style="background-color:#FFFF00">COX</span>) by <span style="background-color:#FFA07A">NSAIDs</span> appears to abort, if not prevent, <span style="background-color:#FFA07A">CRC</span> carcinogenesis or <span style="background-color:#FFA07A">metastatic tumor</span> progression.  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''NSAIDs'''</span> <span style="color:#000080">'''Negative_regulation'''</span> (<span style="color:#000080">inhibition</span>) of <span style="color:#800000">'''COX'''</span>
+
| <span style="color:#800000">'''NSAIDs'''</span> <span style="color:#000080">'''Negative_regulation'''</span> (<span style="color:#000080">inhibition</span>) of <span style="color:#800000">'''COX'''</span> associated with <span style="color:#FF0000">'''colon cancer'''</span>, <span style="color:#FF0000">'''cinod'''</span> and <span style="color:#FF0000">'''metastasis'''</span>
 
|-
 
|-
 
|}
 
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=11275997 11275997]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=11275997 11275997]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.95
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.29
 
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Latest revision as of 13:32, 14 September 2012

Context Info
Confidence 0.03
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.85
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Cpox (Rattus norvegicus)
Pain Term Frequency Confidence Heat
cINOD 35 100.00 Very High Very High Very High
Inflammation 5 97.40 Very High Very High Very High
COX2 6 25.00 Low Low
cytokine 3 25.00 Low Low
COX-2 inhibitor 1 25.00 Low Low
cOX1 2 25.00 Low Low
Disease Term Frequency Confidence Heat
Colon Cancer 13 99.92 Very High Very High Very High
Disease 10 99.88 Very High Very High Very High
Cancer 11 99.44 Very High Very High Very High
INFLAMMATION 10 98.16 Very High Very High Very High
Metastasis 3 97.72 Very High Very High Very High
Inflammatory Bowel Disease 2 97.16 Very High Very High Very High
Apoptosis 1 88.64 High High
Colitis 6 86.56 High High
Malignant Neoplastic Disease 1 80.08 Quite High
Dementia 2 75.12 Quite High

[edit] Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NSAIDs inhibit cyclooxygenase (COX)-1 and/or COX-2 activity, but the chemopreventive effect may be, in part, independent of prostaglandin inhibition.
NSAIDs Negative_regulation (inhibit) of COX associated with cinod
1) Confidence 0.03 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12023546 Disease Relevance 0.46 Pain Relevance 0.87
NSAIDs inhibit cyclooxygenase (COX) activity, thus blocking the endogenous prostaglandin production.
NSAIDs Negative_regulation (inhibit) of COX associated with cinod
2) Confidence 0.01 Published 2004 Journal Expert Opin Investig Drugs Section Abstract Doc Link 15102586 Disease Relevance 0.52 Pain Relevance 0.36
NSAIDs inhibit cyclooxygenase (COX), which has subtypes COX-1 and COX-2.
NSAIDs Negative_regulation (inhibit) of COX associated with cinod
3) Confidence 0.01 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19101538 Disease Relevance 0.66 Pain Relevance 0.66
NSAIDs inhibit cyclooxygenase (COX), of which two isoforms exist.
NSAIDs Negative_regulation (inhibit) of COX associated with cinod
4) Confidence 0.01 Published 2001 Journal Neurobiol. Aging Section Abstract Doc Link 11754989 Disease Relevance 0.74 Pain Relevance 0.30
Blockade of COX enzyme by NSAIDs down-regulates its metabolic product prostaglandin E2.
NSAIDs Negative_regulation (Blockade) of COX enzyme associated with cinod
5) Confidence 0.01 Published 2007 Journal Hepatogastroenterology Section Abstract Doc Link 18019697 Disease Relevance 0.52 Pain Relevance 0.26
Although the exact mechanisms remain unclear, the inhibition of cyclooxygenase (COX) by NSAIDs appears to abort, if not prevent, CRC carcinogenesis or metastatic tumor progression.
NSAIDs Negative_regulation (inhibition) of COX associated with colon cancer, cinod and metastasis
6) Confidence 0.01 Published 2001 Journal Int. J. Cancer Section Abstract Doc Link 11275997 Disease Relevance 0.95 Pain Relevance 0.29

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