INT94647

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Context Info
Confidence 0.0781093500
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in NULL
Documents 6
Total Number 6

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Cpox (Rattus norvegicus)
Pain Relations:

(frequency)

Inflammation (5)

Quite High

Cyclooxygenase 2 (6)

Low Low

cytokines (3)

Low Low

COX-2 inhibitors (1)

Low Low

Cyclooxygenase 1 (2)

Low Low

cyclooxygenase inhibiting NO donators (35)

Low Low

Disease Relations:

(frequency)

disease (10)

Very High Very High Very High

INFLAMMATION (10)

Very High Very High Very High

cancer (11)

High High

apoptosis (1)

High High

colon cancer (13)

High High

inflammatory bowel disease (2)

Quite High

malignant neoplastic disease (1)

Quite High

dementia (2)

Quite High

mutations

Sentences Mentioned In

Key: Protein Event Anatomy Negation Speculation Pain term
NSAIDs inhibit cyclooxygenase (COX)-1 and/or COX-2 activity, but the chemopreventive effect may be, in part, independent of prostaglandin inhibition.
NSAIDs Negative_regulation (inhibit) of COX
1) Confidence 0.0286002491706192 Published 2002 Journal N/A Section N/A Doc Link 12023546
NSAIDs inhibit cyclooxygenase (COX) activity, thus blocking the endogenous prostaglandin production.
NSAIDs Negative_regulation (inhibit) of COX
2) Confidence 0.0134454585956903 Published 2004 Journal N/A Section N/A Doc Link 15102586
NSAIDs inhibit cyclooxygenase (COX), which has subtypes COX-1 and COX-2.
NSAIDs Negative_regulation (inhibit) of COX
3) Confidence 0.0101031507569315 Published 2009 Journal N/A Section N/A Doc Link 19101538
NSAIDs inhibit cyclooxygenase (COX), of which two isoforms exist.
NSAIDs Negative_regulation (inhibit) of COX
4) Confidence 0.00916642503936512 Published 2001 Journal N/A Section N/A Doc Link 11754989
Blockade of COX enzyme by NSAIDs down-regulates its metabolic product prostaglandin E2.
NSAIDs Negative_regulation (Blockade) of COX enzyme
5) Confidence 0.0084229052473169 Published 2007 Journal N/A Section N/A Doc Link 18019697
Although the exact mechanisms remain unclear, the inhibition of cyclooxygenase (COX) by NSAIDs appears to abort, if not prevent, CRC carcinogenesis or metastatic tumor progression.
NSAIDs Negative_regulation (inhibition) of COX
6) Confidence 0.00837119730864821 Published 2001 Journal N/A Section N/A Doc Link 11275997

General Comments

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