INT94647
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Event | Anatomy | Negation | Speculation | Pain term |
NSAIDs inhibit cyclooxygenase (COX)-1 and/or COX-2 activity, but the chemopreventive effect may be, in part, independent of prostaglandin inhibition. | |||||||||||
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NSAIDs inhibit cyclooxygenase (COX) activity, thus blocking the endogenous prostaglandin production. | |||||||||||
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NSAIDs inhibit cyclooxygenase (COX), which has subtypes COX-1 and COX-2. | |||||||||||
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NSAIDs inhibit cyclooxygenase (COX), of which two isoforms exist. | |||||||||||
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Blockade of COX enzyme by NSAIDs down-regulates its metabolic product prostaglandin E2. | |||||||||||
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Although the exact mechanisms remain unclear, the inhibition of cyclooxygenase (COX) by NSAIDs appears to abort, if not prevent, CRC carcinogenesis or metastatic tumor progression. | |||||||||||
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General Comments
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