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Context Info
Confidence 0.0781093500
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in NULL
Documents 6
Total Number 6

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mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Cpox (Rattus norvegicus)
Pain Term Frequency Confidence Heat
Inflammation 5 84.32 Quite High
COX2 6 25 Low Low
cytokine 3 25 Low Low
COX-2 inhibitor 1 25 Low Low
cOX1 2 25 Low Low
cINOD 35 25 Low Low
Disease Term Frequency Confidence Heat
Disease 10 97.72 Very High Very High Very High
INFLAMMATION 10 95.04 Very High Very High Very High
Cancer 11 91.2 High High
Apoptosis 1 88.64 High High
Colon Cancer 13 86.56 High High
Inflammatory Bowel Disease 2 84.32 Quite High
Malignant Neoplastic Disease 1 80.08 Quite High
Dementia 2 65.2 Quite High
Metastasis 3 25 Low Low
Colitis 6 5 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Event Anatomy Negation Speculation Pain term
NSAIDs inhibit cyclooxygenase (COX)-1 and/or COX-2 activity, but the chemopreventive effect may be, in part, independent of prostaglandin inhibition.
NSAIDs Negative_regulation (inhibit) of COX
1) Confidence 0.0286002491706192 Published 2002 Journal N/A Section N/A Doc Link 12023546
NSAIDs inhibit cyclooxygenase (COX) activity, thus blocking the endogenous prostaglandin production.
NSAIDs Negative_regulation (inhibit) of COX
2) Confidence 0.0134454585956903 Published 2004 Journal N/A Section N/A Doc Link 15102586
NSAIDs inhibit cyclooxygenase (COX), which has subtypes COX-1 and COX-2.
NSAIDs Negative_regulation (inhibit) of COX
3) Confidence 0.0101031507569315 Published 2009 Journal N/A Section N/A Doc Link 19101538
NSAIDs inhibit cyclooxygenase (COX), of which two isoforms exist.
NSAIDs Negative_regulation (inhibit) of COX
4) Confidence 0.00916642503936512 Published 2001 Journal N/A Section N/A Doc Link 11754989
Blockade of COX enzyme by NSAIDs down-regulates its metabolic product prostaglandin E2.
NSAIDs Negative_regulation (Blockade) of COX enzyme
5) Confidence 0.0084229052473169 Published 2007 Journal N/A Section N/A Doc Link 18019697
Although the exact mechanisms remain unclear, the inhibition of cyclooxygenase (COX) by NSAIDs appears to abort, if not prevent, CRC carcinogenesis or metastatic tumor progression.
NSAIDs Negative_regulation (inhibition) of COX
6) Confidence 0.00837119730864821 Published 2001 Journal N/A Section N/A Doc Link 11275997

General Comments

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