INT9466

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Context Info
Confidence 0.41
First Reported 1986
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 27
Total Number 28
Disease Relevance 19.36
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (APOB) small molecule metabolic process (APOB) endoplasmic reticulum (APOB)
enzyme binding (APOB) lipid metabolic process (APOB) extracellular space (APOB)
Anatomy Link Frequency
plasma 2
coronary artery 1
liver 1
hip 1
APOB (Homo sapiens)
APOB - T22N (1)
Pain Link Frequency Relevance Heat
Inflammation 162 100.00 Very High Very High Very High
Kinase C 2 93.72 High High
dexamethasone 1 93.72 High High
Angina 28 93.32 High High
cytokine 8 87.56 High High
agonist 31 86.00 High High
Neurobehavioral 2 82.84 Quite High
chemokine 3 80.28 Quite High
GABA receptor 10 61.00 Quite High
gABA 6 57.04 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 596 100.00 Very High Very High Very High
INFLAMMATION 183 100.00 Very High Very High Very High
Cryoglobulinemia 1 100.00 Very High Very High Very High
Disease 440 99.98 Very High Very High Very High
Coronary Artery Disease 226 99.98 Very High Very High Very High
Obesity 255 99.84 Very High Very High Very High
Cardiovascular Disease 182 99.80 Very High Very High Very High
Increased Venous Pressure Under Development 34 98.48 Very High Very High Very High
Repression 1 98.26 Very High Very High Very High
Brain Tumor 2 95.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, these SNPs also showed significant association with TC, TG and ApoB traits.
ApoB Binding (association) of associated with disorder of lipid metabolism
1) Confidence 0.41 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2556320 Disease Relevance 0.60 Pain Relevance 0
The clinical response to long-term reduction of the plasma LDL cholesterol concentration was studied in a man with severe coronary artery disease associated with familial defective apolipoprotein B-100 (FDB).
apolipoprotein B-100 Binding (associated) of in plasma associated with coronary artery disease and disorder of lipid metabolism
2) Confidence 0.37 Published 1992 Journal Atherosclerosis Section Abstract Doc Link 1418096 Disease Relevance 0.49 Pain Relevance 0.09
ApoB is also essential for the binding of LDL particles to the LDL receptor for cellular uptake and degradation of LDL particles (Simon et al. 2005).
ApoB Binding (binding) of
3) Confidence 0.37 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716782 Disease Relevance 0.81 Pain Relevance 0
(Hocher et al. 2003), who have found apoA-I or apoB not to be significantly associated with cardiovascular mortality.
apoB Binding (associated) of
4) Confidence 0.37 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716782 Disease Relevance 0.80 Pain Relevance 0.05
-hydroxysteroid dehydrogenase type 1 (HSD11B1) and apolipoprotein B (APOB) which are all linked to obesity [45]–[47].
APOB Binding (linked) of associated with obesity and disorder of lipid metabolism
5) Confidence 0.36 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2873901 Disease Relevance 0.64 Pain Relevance 0.21
Niacin also increases apo-B100 catabolism causing reduced VLDL and triglyceride secretion by the liver.
apo-B100 Binding (catabolism) of in liver
6) Confidence 0.36 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.05 Pain Relevance 0
Antiapolipoprotein B cryoglobulinemia associated with normal plasma lipids and severe atherosclerosis.
apolipoprotein B Binding (associated) of in plasma associated with cryoglobulinemia and increased venous pressure under development
7) Confidence 0.36 Published 1986 Journal Appl Pathol Section Title Doc Link 3606888 Disease Relevance 0.56 Pain Relevance 0.09
Disease-associated PCSK9 or APOB mutations were not identified in this individual.
APOB Binding (associated) of associated with disease
8) Confidence 0.36 Published 2009 Journal Eur. J. Hum. Genet. Section Abstract Doc Link 18648394 Disease Relevance 0.97 Pain Relevance 0.08
In the existing literature, there is no hard evidence as yet regarding the possible effects of inflammation on apoB levels or the association between apoB and coronary artery disease.
apoB Binding (association) of in coronary artery associated with inflammation and cardiovascular disease
9) Confidence 0.35 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716782 Disease Relevance 0.90 Pain Relevance 0.16
These different associations with waist-hip ratio, HDL-cholesterol and ApoB for men and women by growth environment were significant.
ApoB Binding (associations) of in hip associated with disorder of lipid metabolism
10) Confidence 0.35 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2031823 Disease Relevance 0.75 Pain Relevance 0
-helical domain mediates the interaction with both PDI and apo B; and the C-terminal mediates the lipid-binding and transfer catalytic activity of MTP.
apo B Binding (interaction) of
11) Confidence 0.35 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2467409 Disease Relevance 0.22 Pain Relevance 0
-barrel domain mediates the interaction with the N terminus of apo B; the middle ?
apo B Binding (interaction) of
12) Confidence 0.35 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2467409 Disease Relevance 0.16 Pain Relevance 0
Apolipoprotein A-I (apoA-I) and apoB concentrations were determined by immunoturbodimetric assays (Tina-quant, Roche Diagnostics, Germany).
apoB Spec (determined) Binding (determined) of associated with disorder of lipid metabolism
13) Confidence 0.34 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1360085 Disease Relevance 0.28 Pain Relevance 0
QTL analysis showed suggestive evidence of linkage of the Sac1 SNP to Total Cholesterol (TC), High Density Lipoprotein-cholesterol (HDL-C) and Apolipoprotein B (ApoB) with LOD scores of 1.42, 1.72 and 1.19, respectively (P < 0.01).
ApoB Binding (linkage) of associated with disorder of lipid metabolism
14) Confidence 0.32 Published 2008 Journal Lipids Health Dis Section Abstract Doc Link PMC2556320 Disease Relevance 0.98 Pain Relevance 0
The population average ApoB/ApoA1 ratio (BARP) can be estimated from values for the age and gender-adjusted estimates of TC and HDL using the coefficients in Additional file 1, thus:
ApoB Binding (average) of associated with disorder of lipid metabolism
15) Confidence 0.28 Published 2008 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC2601038 Disease Relevance 1.43 Pain Relevance 0
This may serve the function of reducing futile cycles in TG transport by preserving the particles for high affinity interactions such as with lipoprotein lipase or specific cell surface receptors e.g., such as those binding to apoE or apoB.
apoB Binding (binding) of
16) Confidence 0.15 Published 2002 Journal BMC Genet Section Body Doc Link PMC116591 Disease Relevance 0.61 Pain Relevance 0
This result evidently challenges an independent contributory action of oxLDL to CVD development, and suggests that oxLDL rather serves as a surrogate parameter for apolipoprotein B and total LDL levels.


apolipoprotein B Binding (parameter) of associated with cardiovascular disease and disorder of lipid metabolism
17) Confidence 0.08 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688374 Disease Relevance 0.68 Pain Relevance 0
-hydroxysteroid dehydrogenase type 1 (HSD11B1) and apolipoprotein B (APOB) which are all linked to obesity [45]–[47].
apolipoprotein B Binding (linked) of associated with obesity and disorder of lipid metabolism
18) Confidence 0.07 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2873901 Disease Relevance 0.64 Pain Relevance 0.24
Impaired interaction with one of the known or unknown adiponectin receptors enhanced by low
    SHBG might be hypothesized as an underlying mechanism, perhaps with resulting interaction
    between adiponectin and apo B. 
apo B Binding (interaction) of
19) Confidence 0.04 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 1.40 Pain Relevance 0.19
HDL-cholesterol, apo B and CRP,
   parameters related to pro- and anti-inflammatory processes, showed different associations in the
   sexes. 
apo B Binding (associations) of associated with inflammation and disorder of lipid metabolism
20) Confidence 0.04 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 1.01 Pain Relevance 0.05

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