INT94673

From wiki-pain
Revision as of 15:13, 21 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 12
Disease Relevance 7.77
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (FAAH) cytoplasm (FAAH)
Anatomy Link Frequency
Sertoli cells 3
AT-1 1
lymphocyte 1
FAAH (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 53 99.54 Very High Very High Very High
Endocannabinoid 189 97.60 Very High Very High Very High
rheumatoid arthritis 99 93.88 High High
Osteoarthritis 89 93.60 High High
qutenza 4 89.64 High High
Lasting pain 2 85.44 High High
depression 2 84.32 Quite High
Cannabinoid receptor 35 79.84 Quite High
Inflammation 33 74.52 Quite High
agonist 5 69.48 Quite High
Disease Link Frequency Relevance Heat
Prostate Cancer 408 99.84 Very High Very High Very High
Cancer 619 99.76 Very High Very High Very High
Rheumatoid Arthritis 99 93.88 High High
Frailty 90 93.60 High High
Teratocarcinoma 16 93.56 High High
Disease 221 88.92 High High
Pain 16 85.44 High High
Depression 2 84.32 Quite High
Anxiety Disorder 2 83.12 Quite High
Apoptosis 56 81.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fatty acid amide hydrolase (FAAH) is the enzyme responsible for the rapid degradation of fatty acid amides such as the endocannabinoid anandamide.
Positive_regulation (responsible) of FAAH associated with endocannabinoid
1) Confidence 0.50 Published 2007 Journal J. Neurosci. Methods Section Abstract Doc Link 17083980 Disease Relevance 0.25 Pain Relevance 0.22
Fatty acid amide hydrolase (FAAH) is the enzyme responsible for the rapid degradation of fatty acid amides such as the endocannabinoid anandamide.
Positive_regulation (responsible) of Fatty acid amide hydrolase associated with endocannabinoid
2) Confidence 0.50 Published 2007 Journal J. Neurosci. Methods Section Abstract Doc Link 17083980 Disease Relevance 0.25 Pain Relevance 0.22
We confirmed the presence of IL-4 IR in prostate cancer epithelial tissue (Fig. 2A), and found that incubation of both human androgen-insensitive PC-3 cells and rat Dunning R3327 AT-1 prostate cancer cells with IL-4 for 24 h produced a significant increase in FAAH activity of the cells (Fig. 2B and C).
Positive_regulation (increase) of FAAH in AT-1 associated with prostate cancer
3) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 1.19 Pain Relevance 0.04
The correlation between the Gleason scores and the tumour epithelial FAAH-IR is illustrated in Fig. 1D, where the FAAH-IR is divided into four approximately equal (in sample size) ranges, from the lowest (“I”) to the highest (“IV”).
Positive_regulation (illustrated) of FAAH associated with cancer
4) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.69 Pain Relevance 0
(which decrease FAAH activity in lymphocytes), progesterone, leptin, the TH2 cytokines IL-4 and IL-10 (which increase FAAH activity and FAAH protein content in lymphocytes), and follicle stimulating hormone (which increases FAAH activity in Sertoli cells) [26], [65], [66].
Positive_regulation (increase) of FAAH protein in Sertoli cells associated with cytokine
5) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.70 Pain Relevance 0.13
As the FAAH-IR increases from I to IV, the number of cases with Gleason scores 4–5 decreases, and the number of cases with Gleason scores 8–10 increases.
Positive_regulation (increases) of FAAH
6) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.67 Pain Relevance 0
(which decrease FAAH activity in lymphocytes), progesterone, leptin, the TH2 cytokines IL-4 and IL-10 (which increase FAAH activity and FAAH protein content in lymphocytes), and follicle stimulating hormone (which increases FAAH activity in Sertoli cells) [26], [65], [66].
Positive_regulation (increase) of FAAH in Sertoli cells associated with cytokine
7) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.69 Pain Relevance 0.13
(which decrease FAAH activity in lymphocytes), progesterone, leptin, the TH2 cytokines IL-4 and IL-10 (which increase FAAH activity and FAAH protein content in lymphocytes), and follicle stimulating hormone (which increases FAAH activity in Sertoli cells) [26], [65], [66].
Positive_regulation (increases) of FAAH in Sertoli cells associated with cytokine
8) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.72 Pain Relevance 0.12
However, and at variance with the lymphocyte study of [26], we did not observe any obvious increase in FAAH protein levels following IL-4 treatment, although as a caveat it should be pointed out that the Western blot protocol we used was not fully optimised.
Positive_regulation (increase) of FAAH protein in lymphocyte
9) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.77 Pain Relevance 0.10
Is measurement of FAAH in prostate tumour tissue obtained at diagnosis a potential prognostic marker
Positive_regulation (measurement) of FAAH associated with prostate cancer
10) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.33 Pain Relevance 0
FAAH activity was undetectable in the presence of pharmacological blockade of FAAH by the well-characterised inhibitor of URB597 [58], indicating the functional relevance of this activity.
Positive_regulation (undetectable) of FAAH
11) Confidence 0.38 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453762 Disease Relevance 1.50 Pain Relevance 0.80
Accordingly, hVR1-HEK cells contain an anandamide membrane transporter inhibited by VDM11 and VDM13 and activated by sodium nitroprusside, and an anandamide hydrolase activity sensitive to phenylmethylsulfonyl fluoride and methylarachidonoyl fluorophosphonate, and a fatty acid amide hydrolase transcript.
Positive_regulation (activated) of fatty acid amide hydrolase
12) Confidence 0.32 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11278420 Disease Relevance 0 Pain Relevance 0.33

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox