INT94688

Context Info Confidence 0.21 First Reported 2001 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 4 Total Number 7 Disease Relevance 2.35 Pain Relevance 2.95

protein targeting (Gphn) plasma membrane (Gphn) cytoskeleton (Gphn) intracellular (Gphn) protein binding, bridging (Gphn) cytoplasm (Gphn)

Anatomy Link Frequency spinal cord 2 Gphn (Rattus norvegicus)

Pain Link Frequency Relevance Heat Spinal cord 11 99.82 Kinase C 11 99.78 Opioid 1 99.24 Analgesic 1 98.88 allodynia 31 97.32 narcan 7 96.96 diabetic neuropathy 1 94.72 Dorsal horn 55 92.92 Pain 24 88.52 Pyramidal cell 72 87.68

Disease Link Frequency Relevance Heat Epilepsy 48 98.72 Neuropathic Pain 51 97.32 Nociception 38 94.80 Diabetic Neuropathy 1 94.72 Diabetes Mellitus 2 93.12 Pain 25 88.52 Status Epilepticus 171 85.08 Convulsion 54 85.08 Targeted Disruption 7 82.40 INFLAMMATION 37 80.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We also detected a down-regulation of the gephyrin gene and an up-regulation of the GABARAP gene in accordance with the results obtained from the hippocampi of humans with TLE [86].

Negative_regulation (down-regulation) of gephyrin associated with epilepsy

1) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.34 Pain Relevance 0.10

2 subunit-containing GABAA receptors [87], [88], and the gephyrin down-regulation could further corroborate the hypothesis that the ?

Negative_regulation (down-regulation) of gephyrin

2) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.37 Pain Relevance 0.19

We also detected a down-regulation of the gephyrin (?

Negative_regulation (down-regulation) of gephyrin

3) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.30 Pain Relevance 0.11

In this study, pharmacological effects of a novel PKC-beta isoform selective inhibitor, JTT-010 ((2R)-3-(2-aminomethyl-2,3-dihydro-1H-3a-azacyclopenta(a)inden-8-yl)-4-phenylaminopyrrole-2,5-dione monomethanesulphonate), on diabetic neuropathy were examined.

Spec (examined) Negative_regulation (inhibitor) of isoform associated with kinase c and diabetic neuropathy

4) Confidence 0.06 Published 2005 Journal Diabetes Obes Metab Section Abstract Doc Link 16050952 Disease Relevance 0.34 Pain Relevance 0.35

To test this hypothesis, we used a recently developed, selective inhibitor of the gamma isoform of PKC (KIG31-1) [44]–[47].

Negative_regulation (inhibitor) of isoform

5) Confidence 0.01 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2043493 Disease Relevance 0.61 Pain Relevance 0.40

Enhanced mu-opioid responses in the spinal cord of mice lacking protein kinase Cgamma isoform.

Negative_regulation (lacking) of isoform in spinal cord associated with analgesic, opioid and spinal cord

6) Confidence 0.00 Published 2001 Journal J. Biol. Chem. Section Title Doc Link 11278552 Disease Relevance 0.31 Pain Relevance 1.10

Repeated s.c. administration of naloxone for 7 days resulted in a significant enhancement of the increased [(35)S]GTPgammaS binding by DAMGO to membranes of the spinal cord obtained from mice lacking the protein kinase Cgamma isoform.

Negative_regulation (lacking) of isoform in spinal cord associated with narcan and spinal cord

7) Confidence 0.00 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12566163 Disease Relevance 0.07 Pain Relevance 0.71

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