INT94763

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Context Info
Confidence 0.11
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.72
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PSEN2, App) plasma membrane (PSEN2, App) endoplasmic reticulum (PSEN2)
extracellular matrix organization (App) DNA binding (App) embryo development (PSEN2)
Anatomy Link Frequency
reticulum 4
PSEN2 (Homo sapiens)
App (Mus musculus)
Pain Link Frequency Relevance Heat
Abeta 6 75.00 Quite High
Enkephalin 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Disease 4 99.84 Very High Very High Very High
Alzheimer's Dementia 4 89.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To identify the subcellular compartment(s) in which familial Alzheimer's disease mutant PS2 (mt PS2) affects the gamma-cleavage of betaAPP to increase Abeta42, we co-expressed the C-terminal 99-amino acid fragment of betaAPP (C100) tagged with sorting signals to the endoplasmic reticulum (C100/ER) or to the trans-Golgi network (C100/TGN) together with mt PS2 in N2a cells.
PS2 Regulation (affects) of Positive_regulation (gamma-cleavage) of betaAPP in reticulum associated with disease
1) Confidence 0.11 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11283011 Disease Relevance 0.36 Pain Relevance 0.07
To identify the subcellular compartment(s) in which familial Alzheimer's disease mutant PS2 (mt PS2) affects the gamma-cleavage of betaAPP to increase Abeta42, we co-expressed the C-terminal 99-amino acid fragment of betaAPP (C100) tagged with sorting signals to the endoplasmic reticulum (C100/ER) or to the trans-Golgi network (C100/TGN) together with mt PS2 in N2a cells.
PS2 Regulation (affects) of Positive_regulation (gamma-cleavage) of betaAPP in reticulum associated with disease
2) Confidence 0.10 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11283011 Disease Relevance 0.36 Pain Relevance 0.07

General Comments

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