INT94848

Context Info Confidence 0.30 First Reported 2001 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 11 Total Number 11 Disease Relevance 4.91 Pain Relevance 1.70

cell proliferation (Gpx1) mitochondrion (Gpx1) oxidoreductase activity (Gpx1) nucleus (Gpx1) lipid metabolic process (Gpx1) cytoplasm (Gpx1)

Anatomy Link Frequency brain 6 liver 3 neutrophils 2 blood 1 Gpx1 (Mus musculus)

Pain Link Frequency Relevance Heat Chronic pancreatitis 4 99.92 Pain score 2 97.96 Visceral pain 14 95.44 alcohol 2 75.00 aspirin 49 50.00 Inflammation 24 50.00 Pain 6 25.00 withdrawal 20 5.00 cytokine 9 5.00 endometriosis 6 5.00

Disease Link Frequency Relevance Heat Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 16 99.96 Pancreatitis 5 99.92 Pain 2 97.96 Stress 90 95.76 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super / Visceral Pain 14 95.44 Alcoholic Pancreatitis 4 95.40 Disease 79 89.04 Cognitive Disorder 40 86.00 Dementia 3 51.68 Cataract 45 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Therefore, the increased GPx activity after Se supplementation observed in this study is most likely attributable to GPx1, as potentially counteracts the downregulation of GPx1 expression by long-term Rot treatment. 5.

Negative_regulation (downregulation) of Gene_expression (expression) of GPx1

1) Confidence 0.30 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1925139 Disease Relevance 0.07 Pain Relevance 0

GPx2 (gastrointestinal GPx) and GPx5 (sperm nuclei GPx) have tissue specific localization, while the expression of GPx3 (extracellular GPx) was found to be extremely low in mouse brain 41.

Negative_regulation (low) of Gene_expression (expression) of GPx in brain

2) Confidence 0.26 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1925139 Disease Relevance 0.19 Pain Relevance 0

GPx2 (gastrointestinal GPx) and GPx5 (sperm nuclei GPx) have tissue specific localization, while the expression of GPx3 (extracellular GPx) was found to be extremely low in mouse brain 41.

Negative_regulation (low) of Gene_expression (expression) of GPx in brain

3) Confidence 0.26 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1925139 Disease Relevance 0.18 Pain Relevance 0

GPx2 (gastrointestinal GPx) and GPx5 (sperm nuclei GPx) have tissue specific localization, while the expression of GPx3 (extracellular GPx) was found to be extremely low in mouse brain 41.

Negative_regulation (low) of Gene_expression (expression) of GPx in brain

4) Confidence 0.26 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1925139 Disease Relevance 0.13 Pain Relevance 0

Impaired GPx production and increased production of O2- and H2O2 by neutrophils may result in increased lipid peroxidation and could play a role in the pathogenesis of chronic alcoholic pancreatitis.

Negative_regulation (Impaired) of Gene_expression (production) of GPx in neutrophils associated with alcoholic pancreatitis

5) Confidence 0.16 Published 2001 Journal Pancreas Section Abstract Doc Link 11291927 Disease Relevance 0.84 Pain Relevance 0.38

Assay of GPX activity

Negative_regulation (Assay) of Gene_expression (activity) of GPX

6) Confidence 0.12 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2805669 Disease Relevance 0 Pain Relevance 0

Following CRD we observed (1) all rats expressed signs of visceral pain (overall rating was 1.83), (2) SOD and GPx levels were increased in the liver and blood, and decreased in the brain samples and (3) administration of the antioxidant Trolox, a water-soluble derivate of vitamin E, prior to CRD, prevented SOD and GPx changes in the liver, blood and brain, but did not affect pain scores.

Negative_regulation (prevented) of Gene_expression (changes) of GPx in liver associated with visceral pain and pain score

7) Confidence 0.11 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20417688 Disease Relevance 0.34 Pain Relevance 0.66

Assay of GPx activity

Negative_regulation (Assay) of Gene_expression (activity) of GPx

8) Confidence 0.07 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773744 Disease Relevance 0 Pain Relevance 0

Assay of GPx activity

Negative_regulation (Assay) of Gene_expression (activity) of GPx

9) Confidence 0.05 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994390 Disease Relevance 0 Pain Relevance 0

Following CRD we observed (1) all rats expressed signs of visceral pain (overall rating was 1.83), (2) SOD and GPx levels were increased in the liver and blood, and decreased in the brain samples and (3) administration of the antioxidant Trolox, a water-soluble derivate of vitamin E, prior to CRD, prevented SOD and GPx changes in the liver, blood and brain, but did not affect pain scores.

Negative_regulation (prevented) of in blood Gene_expression (changes) of GPx in liver associated with visceral pain and pain score

10) Confidence 0.04 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20417688 Disease Relevance 0.34 Pain Relevance 0.66

Decreases in the levels or activities of anti-oxidant enzymes, such as SOD and GPx, and of both water soluble and lipophilic antioxidant micronutrients such as vitamins A, C and E, and ?

Negative_regulation (Decreases) of Gene_expression (levels) of GPx

11) Confidence 0.03 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1420275 Disease Relevance 0.68 Pain Relevance 0

General Comments

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