INT94925

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Context Info
Confidence 0.55
First Reported 2001
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 4.23
Pain Relevance 3.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Grip2) plasma membrane (Grip2) cytoskeleton (Grip2)
cytoplasm (Grip2)
Anatomy Link Frequency
spinal cord 2
brain 2
interneurons 2
Grip2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 4 100.00 Very High Very High Very High
Versed 3 100.00 Very High Very High Very High
ketamine 2 100.00 Very High Very High Very High
Glutamate receptor 63 99.98 Very High Very High Very High
Spinal cord 28 99.52 Very High Very High Very High
Hyperalgesia 7 99.52 Very High Very High Very High
Enkephalin 2 99.34 Very High Very High Very High
Dorsal horn 106 99.04 Very High Very High Very High
Inflammation 20 98.92 Very High Very High Very High
tetrodotoxin 12 97.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 174 100.00 Very High Very High Very High
Hyperalgesia 7 99.52 Very High Very High Very High
Infarction 2 99.48 Very High Very High Very High
Neuropathic Pain 25 99.32 Very High Very High Very High
INFLAMMATION 20 98.92 Very High Very High Very High
Nervous System Injury 92 97.28 Very High Very High Very High
Injury 10 95.84 Very High Very High Very High
Death 3 91.72 High High
Cv Unclassified Under Development 1 91.04 High High
Nociception 4 88.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Selective changes in the expression of the flip-flop splice variants of the AMPA receptor suggest a reorganization of the composition of the AMPA receptor complex and its involvement in the development of inflammatory hyperalgesia.
Regulation (changes) of Gene_expression (expression) of AMPA receptor associated with hyperalgesia and inflammation
1) Confidence 0.55 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11295247 Disease Relevance 0.80 Pain Relevance 0.64
In the present study, we used reverse transcription-polymerase chain reaction (RT-PCR) to examine the modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor gene expression in the rat spinal cord by inflammation.
Spec (examine) Regulation (modulation) of Gene_expression (expression) of AMPA in spinal cord associated with inflammation and spinal cord
2) Confidence 0.21 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11295247 Disease Relevance 0.83 Pain Relevance 0.59
Effects of ketamine-midazolam anesthesia on the expression of NMDA and AMPA receptor subunit in the peri-infarction of rat brain.
Regulation (Effects) of Gene_expression (expression) of AMPA receptor subunit in brain associated with anesthesia, versed, ketamine and infarction
3) Confidence 0.08 Published 2006 Journal Chin. Med. J. Section Title Doc Link 16996010 Disease Relevance 0.37 Pain Relevance 0.50
Although AMPA receptor current amplitude was unaffected by CX717 (1.08±0.07 relative to control), current area (charge transfer) and duration increased by 1.23±0.1 and 1.25±0.04 fold (p<0.05, n?
Neg (unaffected) Regulation (unaffected) of Gene_expression (amplitude) of AMPA receptor
4) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808240 Disease Relevance 0 Pain Relevance 0.36
Effect of diabetes on protein expression of AMPA receptor subunits
Regulation (Effect) of Gene_expression (expression) of AMPA associated with diabetes mellitus
5) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 0.74 Pain Relevance 0.05
Effect of diabetes on AMPA receptor subunits gene expression
Regulation (Effect) of Gene_expression (expression) of AMPA receptor subunits gene associated with diabetes mellitus
6) Confidence 0.04 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 0.95 Pain Relevance 0
The alteration in AMPA/NMDA ratio produced by TNF?
Regulation (alteration) of Gene_expression (produced) of AMPA
7) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657778 Disease Relevance 0.53 Pain Relevance 0.52
Metabotropic glutamate receptors modulate the NMDA- and AMPA-induced gene expression in neocortical interneurons.
Regulation (modulate) of Gene_expression (expression) of AMPA-induced in interneurons associated with glutamate receptor and enkephalin
8) Confidence 0.00 Published 2006 Journal Cereb. Cortex Section Title Doc Link 16407481 Disease Relevance 0 Pain Relevance 0.51

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