INT9527

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Context Info
Confidence 0.58
First Reported 1983
Last Reported 1992
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.29
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Avp, Pomc) signal transduction (Avp, Pomc) extracellular region (Avp, Pomc)
cell-cell signaling (Pomc) cytoplasm (Pomc) response to stress (Avp)
Anatomy Mention Frequency
brain 4
Avp (Rattus norvegicus)
Pomc (Rattus norvegicus)
Pain Term Frequency Confidence Heat
Catecholamine 5 100.00 Very High Very High Very High
Kinase C 8 96.48 Very High Very High Very High
Opioid 4 96.08 Very High Very High Very High
anesthesia 1 61.20 Quite High
Morphine 2 45.36 Quite Low
medulla 2 25.00 Low Low
antagonist 4 25.00 Low Low
Disease Term Frequency Confidence Heat
Stress 16 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous work has shown that arginine vasopressin (AVP), which acts in brain primarily via activation of the phosphoinositol (PI) second messenger system, stimulates secretion of hypothalamic beta-endorphin.
arginine vasopressin Positive_regulation (stimulates) of Localization (secretion) of beta-endorphin in brain
1) Confidence 0.58 Published 1992 Journal Brain Res. Bull. Section Abstract Doc Link 1422853 Disease Relevance 0 Pain Relevance 0.27
Previous work has shown that arginine vasopressin (AVP), which acts in brain primarily via activation of the phosphoinositol (PI) second messenger system, stimulates secretion of hypothalamic beta-endorphin.
AVP Positive_regulation (stimulates) of Localization (secretion) of beta-endorphin in brain
2) Confidence 0.58 Published 1992 Journal Brain Res. Bull. Section Abstract Doc Link 1422853 Disease Relevance 0 Pain Relevance 0.27
We conclude that vasopressin does not mediate the catecholamine-induced release of ACTH, beta-endorphin and alpha-MSH.
vasopressin Neg (not) Positive_regulation (mediate) of Localization (release) of beta-endorphin associated with catecholamine
3) Confidence 0.19 Published 1983 Journal Neuroendocrinology Section Abstract Doc Link 6310430 Disease Relevance 0 Pain Relevance 0.15
Recent in vitro studies have shown that the release of hypothalamic beta-endorphin (beta-END), like that of adenohypophysial origin, is enhanced by both corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP).
arginine vasopressin Positive_regulation (enhanced) of Localization (release) of beta-endorphin
4) Confidence 0.12 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1766548 Disease Relevance 0 Pain Relevance 0
Recent in vitro studies have shown that the release of hypothalamic beta-endorphin (beta-END), like that of adenohypophysial origin, is enhanced by both corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP).
AVP Positive_regulation (enhanced) of Localization (release) of beta-endorphin
5) Confidence 0.10 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1766548 Disease Relevance 0 Pain Relevance 0
In addition to corticotropin-releasing factor (CRF) and structurally related peptides, arginine vasopressin (AVP), oxytocin, angiotensin II, vasoactive intestinal polypeptide, peptide histidine isoleucinamide, epinephrine (E), and norepinephrine induce secretion of adrenocorticotropin (ACTH) from corticotropic cells in vitro.
AVP Positive_regulation (induce) of Localization (secretion) of adrenocorticotropin
6) Confidence 0.03 Published 1985 Journal Fed. Proc. Section Abstract Doc Link 2981737 Disease Relevance 0.14 Pain Relevance 0.04
In addition to corticotropin-releasing factor (CRF) and structurally related peptides, arginine vasopressin (AVP), oxytocin, angiotensin II, vasoactive intestinal polypeptide, peptide histidine isoleucinamide, epinephrine (E), and norepinephrine induce secretion of adrenocorticotropin (ACTH) from corticotropic cells in vitro.
vasopressin Positive_regulation (induce) of Localization (secretion) of adrenocorticotropin
7) Confidence 0.02 Published 1985 Journal Fed. Proc. Section Abstract Doc Link 2981737 Disease Relevance 0.14 Pain Relevance 0.04

General Comments

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