INT95415

Context Info Confidence 0.52 First Reported 2000 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.95 Pain Relevance 0.39

transport (Abcd1) mitochondrion (Abcd1) ATPase activity (Abcd1) peroxisome (Abcd1)

Abcd1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 26 99.68 cytokine 14 99.16 Demyelination 1 97.96 anesthesia 2 55.80 Inflammatory response 1 28.80

Disease Link Frequency Relevance Heat Adrenoleukodystrophy 13 100.00 INFLAMMATION 27 99.68 Adrenal Insufficiency 2 99.00 Cancer 2 98.32 Necrosis 2 98.08 Demyelinating Disease 1 97.96 Aging 2 76.44 Disease 10 69.96 Peroxisomal Disorder 1 53.64 Atherosclerosis 5 22.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

All these data indicate that no obvious correlations exist between the phenotypes of ALD patients and their genotypes, suggesting that other genetic or environmental factors may also be involved in determining phenotypic expression in ALD.

Gene_expression (expression) of ALD associated with adrenoleukodystrophy

1) Confidence 0.52 Published 2000 Journal Cell Biochem. Biophys. Section Abstract Doc Link 11330045 Disease Relevance 1.02 Pain Relevance 0.06

In patients with X-ALD, the expression of pro-inflammatory cytokines, including tumor necrosis factor-?

Gene_expression (expression) of X-ALD associated with necrosis, inflammation, cancer and cytokine

2) Confidence 0.08 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2613382 Disease Relevance 0.94 Pain Relevance 0.34

General Comments

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