INT95417

Context Info Confidence 0.48 First Reported 2001 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 5 Disease Relevance 0 Pain Relevance 0.16

signal transduction (Gnrhr) plasma membrane (Gnrhr) signal transducer activity (Gnrhr)

Anatomy Link Frequency follicle 2 Gnrhr (Mus musculus)

Pain Link Frequency Relevance Heat anesthesia 2 83.12 cytokine 3 5.00 Dopamine 3 5.00 adenocard 3 5.00 Inflammation 3 5.00 Pain 3 5.00

Disease Link Frequency Relevance Heat Repression 39 5.00 Targeted Disruption 21 5.00 Syndrome 18 5.00 Premature Ovarian Failure 15 5.00 Adhesions 6 5.00 Ocular Toxicity (including Many Sub-types) 6 5.00 Blepharophimosis 6 5.00 Apoptosis 6 5.00 Cancer 6 5.00 Herpes Simplex Virus 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Studies in the mouse have demonstrated for the first time in vivo regulation of gonadotropin-releasing hormone (GnRH) on the minute-to-minute dynamics of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release and the effects of testosterone on this regulation.

Regulation (regulation) of gonadotropin-releasing hormone in follicle

1) Confidence 0.48 Published 2001 Journal J. Androl. Section Abstract Doc Link 11330652 Disease Relevance 0 Pain Relevance 0.08

Testosterone effects on luteinizing hormone and follicle-stimulating hormone responses to gonadotropin-releasing hormone in the mouse.

Regulation (responses) of gonadotropin-releasing hormone in follicle

2) Confidence 0.35 Published 2001 Journal J. Androl. Section Title Doc Link 11330652 Disease Relevance 0 Pain Relevance 0.08

One identified target, the gonadotropin releasing hormone receptor (GnRHR) gene, was chosen for further study and validation of Foxl2 responsiveness.

Regulation (responsiveness) of gonadotropin releasing hormone receptor

3) Confidence 0.22 Published 2010 Journal J Ovarian Res Section Abstract Doc Link PMC2831895 Disease Relevance 0 Pain Relevance 0

One identified target, the gonadotropin releasing hormone receptor (GnRHR) gene, was chosen for further study and validation of Foxl2 responsiveness.

Regulation (target) of GnRHR

4) Confidence 0.22 Published 2010 Journal J Ovarian Res Section Abstract Doc Link PMC2831895 Disease Relevance 0 Pain Relevance 0

One identified target, the gonadotropin releasing hormone receptor (GnRHR) gene, was chosen for further study and validation of Foxl2 responsiveness.

Regulation (target) of gonadotropin releasing hormone receptor

5) Confidence 0.22 Published 2010 Journal J Ovarian Res Section Abstract Doc Link PMC2831895 Disease Relevance 0 Pain Relevance 0

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