INT95650

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.41
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf) extracellular space (Ngf) extracellular region (Ngf)
Anatomy Link Frequency
neurons 2
eosinophil 2
Ngf (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 141 100.00 Very High Very High Very High
Inflammation 11 100.00 Very High Very High Very High
dexamethasone 1 95.40 Very High Very High Very High
Thermal hyperalgesia 2 91.80 High High
tail-flick 1 91.76 High High
Hyperalgesia 5 90.56 High High
Thalamus 1 90.08 High High
Pyramidal cell 3 87.20 High High
Spinal cord 8 87.04 High High
cytokine 5 85.36 High High
Disease Link Frequency Relevance Heat
Eczema 108 100.00 Very High Very High Very High
Pruritus 24 100.00 Very High Very High Very High
Injury 9 100.00 Very High Very High Very High
INFLAMMATION 9 100.00 Very High Very High Very High
Erythema 3 100.00 Very High Very High Very High
Necrosis 2 100.00 Very High Very High Very High
Cancer 2 100.00 Very High Very High Very High
Leishmaniasis 7 99.64 Very High Very High Very High
Stress 2 97.44 Very High Very High Very High
Nociception 2 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mice with CL showed sustained increase in the levels of IL-1beta and NGF which were reversed by thymulin (1 microg).
Negative_regulation (reversed) of Positive_regulation (increase) of NGF associated with leishmaniasis and nerve growth factor
1) Confidence 0.43 Published 2002 Journal Brain Behav. Immun. Section Abstract Doc Link 12096890 Disease Relevance 0.92 Pain Relevance 0.80
The increase in NGF protein preceded the increase in mRNA, suggesting that this increase was not the result of gene transcription.
Negative_regulation (preceded) of Positive_regulation (increase) of NGF protein
2) Confidence 0.43 Published 2001 Journal BJU Int. Section Body Doc Link 11350415 Disease Relevance 0.10 Pain Relevance 0
The level of NGF was significantly higher in AD patients than in healthy controls, correlated with the severity of itch, erythema, scale/xerosis, the eosinophil count and LDH level, and also significantly decreased after treatments with olopatadine and/or steroid ointment for 2 and 4 weeks.
Negative_regulation (decreased) of Positive_regulation (level) of NGF in eosinophil associated with erythema, nerve growth factor, pruritus and eczema
3) Confidence 0.39 Published 2010 Journal Allergy, Asthma & Immunology Research Section Abstract Doc Link PMC2946701 Disease Relevance 1.13 Pain Relevance 0.35
Adrenalectomy prevents the trauma-induced increase in NGF, underscoring the essential role of endogenous glucocorticoids in inducing the protective neurotrophins [77].
Negative_regulation (prevents) of Positive_regulation (increase) of NGF associated with nerve growth factor and injury
4) Confidence 0.37 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 1.19 Pain Relevance 0.50
During the third week of embryonic development, an increasing number of small neurons in DRG initiates ret expression, while expression in sympathetic ganglia is restricted to a subset of neurons thus distinguishing a “progressive increase” from a “progressive restriction” of gene expression to neuron subpopulations (arrow NGF requirement for the increase in the ret-positive population in DRG)Fig. 5Cholineric differentiation of sympathetic neurons during mouse embryogenesis.
Negative_regulation (distinguishing) of in neurons Positive_regulation (requirement) of NGF in neuron associated with nerve growth factor
5) Confidence 0.27 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.09 Pain Relevance 0.05
Behavioral deficits were coupled with enhanced oxidative-nitrosative stress as evident by increased lipid peroxidation, nitrite levels and decreased endogenous antioxidant enzymes (superoxide dismutase, reduced glutathione and catalase) and inflammation (increased levels of tumor necrosis factor-alpha and tissue growth factor-beta).
Negative_regulation (reduced) of Positive_regulation (increased) of tissue growth factor-beta associated with stress, necrosis, inflammation and cancer
6) Confidence 0.18 Published 2009 Journal Behav. Brain Res. Section Abstract Doc Link 19643148 Disease Relevance 0.97 Pain Relevance 0.14

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