INT9567

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Context Info
Confidence 0.44
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 2.14
Pain Relevance 5.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nts)
Anatomy Link Frequency
smooth muscle 1
pancreas 1
nerve 1
brain 1
Nts (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 82 100.00 Very High Very High Very High
qutenza 13 100.00 Very High Very High Very High
bradykinin 10 100.00 Very High Very High Very High
Antinociceptive 5 100.00 Very High Very High Very High
nociceptor 5 100.00 Very High Very High Very High
Enkephalin 6 99.80 Very High Very High Very High
Intracerebroventricular 2 99.44 Very High Very High Very High
opioid receptor 3 99.32 Very High Very High Very High
Dopamine 1 99.04 Very High Very High Very High
substance P 5 96.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Clostridium Infection 1 100.00 Very High Very High Very High
Pancreatic Cancer 9 98.76 Very High Very High Very High
Nociception 2 98.36 Very High Very High Very High
Pancreatitis 10 96.72 Very High Very High Very High
Disease 2 93.96 High High
Depression 1 93.40 High High
Drug Dependence 1 92.80 High High
Pain 75 90.52 High High
Stress 2 90.16 High High
Hypothermia 3 74.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interactions between NTS2 neurotensin and opioid receptors on two nociceptive responses assessed on the hot plate test in mice.
NTS2 Binding (Interactions) of associated with nociception and opioid receptor
1) Confidence 0.44 Published 2006 Journal Behav. Brain Res. Section Title Doc Link 17074405 Disease Relevance 0.19 Pain Relevance 0.85
The aim of this paper was to study the interaction between neurotensin and both enkephalins or its synthetic analogue D-Ala2-metenkephalinamide, or tuftsin, on the antinonciceptive effect of these peptides in mice after intracisternal injection.
neurotensin Binding (interaction) of associated with enkephalin
2) Confidence 0.37 Published 1984 Journal Acta Physiol Pol Section Abstract Doc Link 6545985 Disease Relevance 0 Pain Relevance 0.51
Interaction on the antinociceptive effect between neurotensin and enkephalins or tuftsin.
neurotensin Binding (Interaction) of associated with nociceptor, enkephalin and antinociceptive
3) Confidence 0.37 Published 1984 Journal Acta Physiol Pol Section Title Doc Link 6545985 Disease Relevance 0 Pain Relevance 0.88
The second part focuses on functional-anatomical interactions between NT, the mesotelencephalic dopamine system and structures targeted by dopaminergic projections.
NT Binding (interactions) of associated with dopamine
4) Confidence 0.31 Published 2006 Journal Peptides Section Abstract Doc Link 16934369 Disease Relevance 0.44 Pain Relevance 0.23
The antihistaminic drug levocabastine is a ligand for the low affinity neurotensin receptor (NTS2).
NTS2 Binding (ligand) of
5) Confidence 0.28 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10528128 Disease Relevance 0.05 Pain Relevance 0.48
We recently reported that H-Lys psi (CH2NH)Lys-Pro-Tyr-Ile-Leu-OH (JMV 449), a pseudopeptide analogue of neurotensin-(8-13) with a reduced CH2NH bond in position 8-9, was about 3 times more potent than neurotensin in binding to mouse brain membranes and in contracting the guinea-pig ileum, and was markedly more resistant to degradation than neurotensin when exposed to rat brain membranes.
neurotensin Binding (binding) of in brain
6) Confidence 0.27 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1425958 Disease Relevance 0.07 Pain Relevance 0.21
The data suggest that the action of NT involves interaction with receptors on toad intestinal smooth muscle that recognize the C-terminal region of NT (residues 8-13) that has been fully conserved during evolution of tetrapods.
NT Binding (recognize) of in smooth muscle
7) Confidence 0.25 Published 1998 Journal Peptides Section Abstract Doc Link 9786176 Disease Relevance 0 Pain Relevance 0.14
The results were interpreted as an indication that NT, BK and CAP produce their excitatory effects in guinea pig atria by interacting with a common population of CAP-sensitive sensory nerve fibers (presumably substance P (SP)- and CGRP-containing nerve fibers).
NT Binding (interacting) of in nerve associated with qutenza, bradykinin, calcitonin gene-related peptide and substance p
8) Confidence 0.10 Published 1988 Journal Peptides Section Abstract Doc Link 3265787 Disease Relevance 0 Pain Relevance 1.75
Botulinum neurotoxin (BoNT) is produced by Clostridium botulinum as a complex of proteins containing the neurotoxic moiety associated with nontoxic components.
BoNT Binding (complex) of associated with clostridium infection
9) Confidence 0.02 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004655 Disease Relevance 0.81 Pain Relevance 0.57
By autoradiography, neurotensin (NT) binding is specifically detectable in pancreatic cancer, but not in the normal pancreas, chronic pancreatitis (CP), or other pancreatic disorders.
neurotensin Binding (binding) of in pancreas associated with pancreatic cancer and chronic pancreatitis
10) Confidence 0.01 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10690540 Disease Relevance 0.57 Pain Relevance 0.26

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