INT9567

Context Info Confidence 0.44 First Reported 1984 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 10 Total Number 10 Disease Relevance 2.14 Pain Relevance 5.89

extracellular region (Nts)

Anatomy Link Frequency smooth muscle 1 pancreas 1 nerve 1 brain 1 Nts (Mus musculus)

Pain Link Frequency Relevance Heat Pain 82 100.00 qutenza 13 100.00 bradykinin 10 100.00 Antinociceptive 5 100.00 nociceptor 5 100.00 Enkephalin 6 99.80 Intracerebroventricular 2 99.44 opioid receptor 3 99.32 Dopamine 1 99.04 substance P 5 96.96

Disease Link Frequency Relevance Heat Clostridium Infection 1 100.00 Pancreatic Cancer 9 98.76 Nociception 2 98.36 Pancreatitis 10 96.72 Disease 2 93.96 Depression 1 93.40 Drug Dependence 1 92.80 Pain 75 90.52 Stress 2 90.16 Hypothermia 3 74.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interactions between NTS2 neurotensin and opioid receptors on two nociceptive responses assessed on the hot plate test in mice.

NTS2 Binding (Interactions) of associated with nociception and opioid receptor

1) Confidence 0.44 Published 2006 Journal Behav. Brain Res. Section Title Doc Link 17074405 Disease Relevance 0.19 Pain Relevance 0.85

The aim of this paper was to study the interaction between neurotensin and both enkephalins or its synthetic analogue D-Ala2-metenkephalinamide, or tuftsin, on the antinonciceptive effect of these peptides in mice after intracisternal injection.

neurotensin Binding (interaction) of associated with enkephalin

2) Confidence 0.37 Published 1984 Journal Acta Physiol Pol Section Abstract Doc Link 6545985 Disease Relevance 0 Pain Relevance 0.51

Interaction on the antinociceptive effect between neurotensin and enkephalins or tuftsin.

neurotensin Binding (Interaction) of associated with nociceptor, enkephalin and antinociceptive

3) Confidence 0.37 Published 1984 Journal Acta Physiol Pol Section Title Doc Link 6545985 Disease Relevance 0 Pain Relevance 0.88

The second part focuses on functional-anatomical interactions between NT, the mesotelencephalic dopamine system and structures targeted by dopaminergic projections.

NT Binding (interactions) of associated with dopamine

4) Confidence 0.31 Published 2006 Journal Peptides Section Abstract Doc Link 16934369 Disease Relevance 0.44 Pain Relevance 0.23

The antihistaminic drug levocabastine is a ligand for the low affinity neurotensin receptor (NTS2).

NTS2 Binding (ligand) of

5) Confidence 0.28 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10528128 Disease Relevance 0.05 Pain Relevance 0.48

We recently reported that H-Lys psi (CH2NH)Lys-Pro-Tyr-Ile-Leu-OH (JMV 449), a pseudopeptide analogue of neurotensin-(8-13) with a reduced CH2NH bond in position 8-9, was about 3 times more potent than neurotensin in binding to mouse brain membranes and in contracting the guinea-pig ileum, and was markedly more resistant to degradation than neurotensin when exposed to rat brain membranes.

neurotensin Binding (binding) of in brain

6) Confidence 0.27 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1425958 Disease Relevance 0.07 Pain Relevance 0.21

The data suggest that the action of NT involves interaction with receptors on toad intestinal smooth muscle that recognize the C-terminal region of NT (residues 8-13) that has been fully conserved during evolution of tetrapods.

NT Binding (recognize) of in smooth muscle

7) Confidence 0.25 Published 1998 Journal Peptides Section Abstract Doc Link 9786176 Disease Relevance 0 Pain Relevance 0.14

The results were interpreted as an indication that NT, BK and CAP produce their excitatory effects in guinea pig atria by interacting with a common population of CAP-sensitive sensory nerve fibers (presumably substance P (SP)- and CGRP-containing nerve fibers).

NT Binding (interacting) of in nerve associated with qutenza, bradykinin, calcitonin gene-related peptide and substance p

8) Confidence 0.10 Published 1988 Journal Peptides Section Abstract Doc Link 3265787 Disease Relevance 0 Pain Relevance 1.75

Botulinum neurotoxin (BoNT) is produced by Clostridium botulinum as a complex of proteins containing the neurotoxic moiety associated with nontoxic components.

BoNT Binding (complex) of associated with clostridium infection

9) Confidence 0.02 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004655 Disease Relevance 0.81 Pain Relevance 0.57

By autoradiography, neurotensin (NT) binding is specifically detectable in pancreatic cancer, but not in the normal pancreas, chronic pancreatitis (CP), or other pancreatic disorders.

neurotensin Binding (binding) of in pancreas associated with pancreatic cancer and chronic pancreatitis

10) Confidence 0.01 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10690540 Disease Relevance 0.57 Pain Relevance 0.26

General Comments

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