INT95695

Context Info Confidence 0.19 First Reported 2001 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.80 Pain Relevance 0.47

signal transduction (Chrnb1) transport (Chrnb1) plasma membrane (Chrnb1) neurological system process (Chrnb1)

Anatomy Link Frequency muscle fiber 1 Chrnb1 (Mus musculus)

Pain Link Frequency Relevance Heat Neuronal nitric oxide synthase 2 99.80 cytokine 37 98.12 lidocaine 1 75.28 fibrosis 1 53.12 Inflammation 13 50.24 Multiple sclerosis 2 33.60 Inflammatory response 1 24.00 alcohol 1 12.96 adenocard 11 5.00 substance P 4 5.00

Disease Link Frequency Relevance Heat Muscle Weakness 1 95.24 Disease 34 90.76 Myasthenia Gravis 2 87.44 Autoimmune Disease 8 82.28 Neurodegenerative Disease 10 62.16 Pulmonary Fibrosis 1 53.52 Inflammatory Bowel Disease 1 50.24 Asthma 1 43.84 Apoptosis 3 38.16 Multiple Sclerosis 4 33.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We investigated whether the changes in acetylcholine receptor (AChR) distribution and neuronal nitric oxide synthase (nNOS) expression reported for the skeletal muscle of mdx mice were a consequence of muscle fiber regeneration rather than of the absence of dystrophin.

Transcription (distribution) of AChR in muscle fiber associated with neuronal nitric oxide synthase

1) Confidence 0.19 Published 2001 Journal Muscle Nerve Section Abstract Doc Link 11353428 Disease Relevance 0 Pain Relevance 0.16

The effect of cytokines on acetylocholine receptor expression was studied by Poea-Guyon et al (2005), who found that AchR transcripts are up-regulated by IFN?

Transcription (transcripts) of AchR associated with cytokine

2) Confidence 0.05 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654796 Disease Relevance 0.80 Pain Relevance 0.31

General Comments

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