INT95756

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Context Info
Confidence 0.27
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.49
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ACO1) mitochondrion (ACO1) lyase activity (ACO1)
Golgi apparatus (ACO1) endoplasmic reticulum (ACO1) RNA binding (ACO1)
Anatomy Link Frequency
hepatocytes 1
ACO1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 1 68.24 Quite High
imagery 1 64.40 Quite High
Inflammation 48 47.56 Quite Low
Pain 4 10.24 Low Low
cytokine 21 5.00 Very Low Very Low Very Low
fibrosis 19 5.00 Very Low Very Low Very Low
Inflammatory response 11 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Iron Overload 53 97.52 Very High Very High Very High
Adrenoleukodystrophy 3 95.00 High High
Disease 73 90.04 High High
Anaemia 36 87.72 High High
Stress 115 86.12 High High
Injury 46 79.88 Quite High
Muscle Hypotonia 1 74.24 Quite High
Convulsion 1 72.64 Quite High
Ocular Toxicity (including Many Sub-types) 2 70.48 Quite High
Disease Progression 2 63.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cytosolic iron sensors IRP1, which senses iron levels through an iron?
Gene_expression (sensors) of IRP1
1) Confidence 0.27 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.34 Pain Relevance 0
S proteins, including aconitase and succinate dehydrogenase, fail to acquire their Fe?
Neg (fail) Gene_expression (fail) of aconitase
2) Confidence 0.27 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.79 Pain Relevance 0
Another concept should be recalled: intracellular levels of iron are usually carefully controlled (as in hepatocytes or macrophages) by means of iron binding to cytoplasmic Iron regulatory proteins (IRP-1 and IRP-2) and the expression of genes involved in iron homeostasis through the binding of IRPs to Iron responsive element (IRE) sequences, including those for transferrin receptor (TfR) and ferritin (Ft).
Gene_expression (expression) of IRP-1 in hepatocytes
3) Confidence 0.06 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.90 Pain Relevance 0
The disorders of peroxisomal beta-oxidation, which have been well characterised at the molecular level, include defects of acyl-CoA oxidase, defects of the D-bifunctional protein (D-BP) (including specific defects of its enoyl-CoA hydratase and D-3-hydroxyacyl-CoA dehydrogenase components), defects of the very-long-chain fatty acid (VLCFA)-CoA importer [X-linked adrenoleukodystrophy (ALD)] and alpha-methylacyl-CoA racemase deficiency.
Gene_expression (defects) of hydratase associated with adrenoleukodystrophy
4) Confidence 0.00 Published 2001 Journal Biochem. Soc. Trans. Section Abstract Doc Link 11356171 Disease Relevance 0.46 Pain Relevance 0.10

General Comments

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