INT96071

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Context Info
Confidence 0.71
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.44
Pain Relevance 3.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PIAS1) nucleus (PIAS1) enzyme binding (PIAS1)
DNA binding (PIAS1) ligase activity (PIAS1)
Anatomy Link Frequency
neocortex 2
brain 1
PIAS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Gabapentin 31 100.00 Very High Very High Very High
pregabalin 6 100.00 Very High Very High Very High
Neurotransmitter 5 100.00 Very High Very High Very High
noradrenaline 3 100.00 Very High Very High Very High
anticonvulsant 2 99.74 Very High Very High Very High
Hippocampus 9 99.12 Very High Very High Very High
agonist 3 98.48 Very High Very High Very High
antagonist 2 95.52 Very High Very High Very High
Calcium channel 6 94.84 High High
carbamazepine 2 94.44 High High
Disease Link Frequency Relevance Heat
Epilepsy 45 99.52 Very High Very High Very High
Cholecystitis 1 94.48 High High
Thrombosis 2 90.48 High High
Cancer 6 88.88 High High
Gallstones 7 86.12 High High
Acute Cholecystitis 5 84.20 Quite High
Malignant Neoplastic Disease 1 80.20 Quite High
Diabetes Mellitus 1 78.56 Quite High
Cardiovascular Disease 1 78.04 Quite High
Atherosclerosis 1 77.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that GBP and PGB are not general inhibitors of VSCC and neurotransmitter release.
Localization (release) of GBP associated with pregabalin, neurotransmitter and gabapentin
1) Confidence 0.71 Published 2008 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 18074120 Disease Relevance 0.05 Pain Relevance 1.32
The modulation of K(+)-evoked [(3)H]-norepinephrine ([(3)H]-NE) release by gabapentin (GBP) and pinacidil (PIN), a known K(ATP) agonist, was examined in human brain slices.
Localization (release) of GBP in brain associated with agonist and gabapentin
2) Confidence 0.66 Published 2006 Journal Neurosci. Res. Section Abstract Doc Link 16650496 Disease Relevance 0.75 Pain Relevance 0.51
The data show a marked reduction in K(+)-evoked [(3)H]-NE release by GBP and PIN in epileptic hippocampus and neocortex, suggesting an alteration of K(ATP) channel function, whereas the effects of the calcium channel modulators omega-conotoxins MVIIA and MVIIC are similar in both epileptic and non-epileptic neocortex.
Localization (release) of GBP in neocortex associated with epilepsy, calcium channel, hippocampus and gabapentin
3) Confidence 0.57 Published 2006 Journal Neurosci. Res. Section Abstract Doc Link 16650496 Disease Relevance 1.27 Pain Relevance 0.65
GBP (100 microM) decreased [(3)H]-NE release by 22% in non-epileptic neocortical slices, whereas this inhibition was absent in slices from epileptic hippocampus and epileptic neocortex.
Localization (release) of GBP in neocortex associated with epilepsy, hippocampus and gabapentin
4) Confidence 0.57 Published 2006 Journal Neurosci. Res. Section Abstract Doc Link 16650496 Disease Relevance 1.09 Pain Relevance 0.62
The cause of GBP remains unclear.
Localization (cause) of GBP
5) Confidence 0.53 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2887867 Disease Relevance 1.28 Pain Relevance 0.03
To elucidate the mechanism of action of the anticonvulsant gabapentin (GBP), we compared its effects on K+-evoked [3H]-noradrenaline ([3H]-NA) release from rat hippocampal and human neocortical slices with those of the KATP channel opener pinacidil and the Na+ channel blockers phenytoin, carbamazepine and lamotrigine.
Localization (release) of GBP associated with lamotrigine, noradrenaline, anticonvulsant, gabapentin and carbamazepine
6) Confidence 0.36 Published 2001 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11383714 Disease Relevance 0 Pain Relevance 0.66

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