INT96151

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Context Info
Confidence 0.58
First Reported 2001
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 6.06
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd40) extracellular region (Cd40) plasma membrane (Cd40)
enzyme binding (Cd40)
Anatomy Link Frequency
microglial cells 18
coronary artery 2
CD86 2
myeloid dendritic cells 2
Kupffer cells 2
Cd40 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 16 99.68 Very High Very High Very High
cytokine 188 98.36 Very High Very High Very High
Multiple sclerosis 224 98.12 Very High Very High Very High
Central nervous system 99 97.44 Very High Very High Very High
rheumatoid arthritis 57 97.28 Very High Very High Very High
Analgesic 1 96.36 Very High Very High Very High
Cannabinoid 44 95.92 Very High Very High Very High
agonist 163 95.68 Very High Very High Very High
aspirin 11 94.92 High High
Inflammatory response 34 93.40 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 17 99.16 Very High Very High Very High
Autoimmune Disease 58 99.10 Very High Very High Very High
Cardiovascular Disease 18 98.24 Very High Very High Very High
Multiple Sclerosis 126 98.12 Very High Very High Very High
Disease 410 97.68 Very High Very High Very High
Central Nervous System Disease 27 97.44 Very High Very High Very High
Rheumatoid Arthritis 57 97.28 Very High Very High Very High
INFLAMMATION 332 97.20 Very High Very High Very High
Neurodegenerative Disease 67 97.12 Very High Very High Very High
Acute Coronary Syndrome 2 96.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since CTLA4-Ig mediated co-stimulatory blockade induces remission of autoimmunity, we sought to determine whether a temporary suppression of CD40 expression by administration of siRNA may induce immune modulatory effects on RA that predispose towards reduction of immunity towards the autoantigen.
Negative_regulation (suppression) of Gene_expression (expression) of CD40 associated with autoimmune disease and rheumatoid arthritis
1) Confidence 0.58 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.64 Pain Relevance 0.18
As expected, the treatment of cultured microglial cells with THC, CP55940 and JWH-015 significantly inhibited CD40 expression induced by IFN-?
Negative_regulation (inhibited) of Gene_expression (expression) of CD40 in microglial cells
2) Confidence 0.52 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.09
Further, to determine if this reduction in CD40 expression continues through microglial activation, we treated both N9 and primary microglia cells with 25 ?
Negative_regulation (reduction) of Gene_expression (expression) of CD40 in microglia
3) Confidence 0.51 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.17 Pain Relevance 0
In sedentary TG animals, a trend of reduced expression of CD40 is present compared to WTSED (p = 0.10), but there is a significant elevation in CD40 from TGSED to TGRUN (p = 0.008) (Figure 4).
Negative_regulation (reduced) of Gene_expression (expression) of CD40
4) Confidence 0.46 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2329612 Disease Relevance 0.06 Pain Relevance 0.08
Decreased IgM-RF and ACPA levels after rituximab treatment
Negative_regulation (Decreased) of Gene_expression (levels) of IgM
5) Confidence 0.41 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564787 Disease Relevance 0 Pain Relevance 0.04
At 24 weeks the serum levels of IgM-RF and ACPA decreased significantly more than those of their respective antibody classes (p?
Negative_regulation (decreased) of Gene_expression (levels) of IgM
6) Confidence 0.41 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564787 Disease Relevance 0 Pain Relevance 0.03
There was a highly significant decrease in serum levels of IgM-RF at 16 (p?
Negative_regulation (decrease) of Gene_expression (was) of IgM
7) Confidence 0.41 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564787 Disease Relevance 0 Pain Relevance 0.03
We recently reported that lovastatin treatment inhibits CD40 expression in cultured microglial cells [34].
Negative_regulation (inhibits) of Gene_expression (expression) of CD40 in microglial cells
8) Confidence 0.39 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.08
Stimulation of CB2 inhibits functional CD40 signaling in microglial cells
Negative_regulation (inhibits) of Gene_expression (signaling) of CD40 in microglial cells
9) Confidence 0.38 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.13 Pain Relevance 0.24
Taken together, these findings suggest that stimulation of CB2 decreases CD40 expression on primary cultured microglial cells.


Negative_regulation (decreases) of Gene_expression (expression) of CD40 in microglial cells
10) Confidence 0.38 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.08
Our findings demonstrate that treatment of both N9 and murine-derived primary microglia cell lines with apigenin and luteolin significantly reduces CD40 expression induced by IFN-?.
Negative_regulation (reduces) of Gene_expression (expression) of CD40 in microglia
11) Confidence 0.38 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.57 Pain Relevance 0.26
Following FACS analysis, we found that both compounds significantly reduced CD40 expression on the microglial cell surface (p < 0.01, Fig. 1).
Negative_regulation (reduced) of Gene_expression (expression) of CD40 in microglial cell
12) Confidence 0.38 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.14 Pain Relevance 0
Here, we identify two flavonoids, apigenin and luteolin, that reduce CD40 expression on microglia and elucidate a mechanism whereby these compounds may prevent harmful neuroinflammation.
Negative_regulation (reduce) of Gene_expression (expression) of CD40 in microglia
13) Confidence 0.38 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.10 Pain Relevance 0
In this study, at physiological concentrations, it profoundly inhibited CD40, CD80, CD86, and MHC class II expression on murine, GM-CSF + IL-4 stimulated, bone marrow-derived myeloid dendritic cells (DC).
Negative_regulation (inhibited) of Gene_expression (expression) of CD40 in myeloid dendritic cells
14) Confidence 0.36 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11390449 Disease Relevance 0.10 Pain Relevance 0.31
TGSED, we examined CD40 and MHC II protein expression in the hippocampus via western blot.
Spec (examined) Negative_regulation (examined) of Spec (examined) Gene_expression (expression) of CD40 in hippocampus associated with hippocampus
15) Confidence 0.34 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2329612 Disease Relevance 0 Pain Relevance 0.19
Similarly, oxidant generating enzyme inhibitors, such as diphenyleneiodonium and allopurinol, suppressed high expression of MHC class II, CD40, and CD80 in rat Kupffer cells after antigen challenge (Maemura et al., 2005).
Negative_regulation (suppressed) of Gene_expression (expression) of CD40 in Kupffer cells
16) Confidence 0.30 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0
Treatment with rosiglitazone decreased the serum levels of soluble CD40 and MMP-9 in type 2 diabetic patients with coronary artery disease [53].
Negative_regulation (decreased) of Gene_expression (levels) of CD40 in coronary artery associated with cardiovascular disease and diabetes mellitus
17) Confidence 0.23 Published 2010 Journal PPAR Research Section Body Doc Link PMC2931381 Disease Relevance 1.46 Pain Relevance 0.11
Our results show decreased expression of microglial CD40 and reduction in both CNS and peripheral sCD40L concomitant with HUCBC-induced diminished AD-like pathology, raising the possibility that disruption of CD40-CD40L interaction may be responsible for mitigation of AD-like pathology in this scenario [183].
Negative_regulation (decreased) of Gene_expression (expression) of CD40 associated with disease
18) Confidence 0.19 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2615427 Disease Relevance 0.95 Pain Relevance 0.14
It has been demonstrated that both a microglial cell-specific deficiency of CD40 expression and a transient inactivation of microglial cells reduce disease severity [201].
Negative_regulation (deficiency) of Gene_expression (expression) of CD40 in microglial cell associated with disease
19) Confidence 0.16 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 1.23 Pain Relevance 0.31
studies indicated that 15d-PGJ2 inhibited microglial expression of CD40,
Negative_regulation (inhibited) of Gene_expression (expression) of CD40
20) Confidence 0.14 Published 2008 Journal PPAR Research Section Body Doc Link PMC2441778 Disease Relevance 0.54 Pain Relevance 0.42

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