INT96472

Context Info Confidence 0.01 First Reported 2001 Last Reported 2001 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.22 Pain Relevance 0.64

plasma membrane (KNG1, TRPV1) cytosol (TRPV1) transport (TRPV1) extracellular space (KNG1) extracellular region (KNG1) lipid metabolic process (TRPV1)

Anatomy Link Frequency sensory neurons 2 KNG1 (Homo sapiens) TRPV1 (Homo sapiens)

Pain Link Frequency Relevance Heat Nerve growth factor 7 100.00 bradykinin 5 100.00 Pain 2 81.64 qutenza 1 75.00 TRP channel 1 47.68 nociceptor 1 25.00

Disease Link Frequency Relevance Heat Pain 1 81.64 Injury 1 79.20 Hypersensitivity 1 56.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Here, we show that bradykinin- or NGF-mediated potentiation of thermal sensitivity in vivo requires expression of VR1, a heat-activated ion channel on sensory neurons.

bradykinin Positive_regulation (requires) of Gene_expression (expression) of VR1 in sensory neurons associated with nerve growth factor and bradykinin

1) Confidence 0.01 Published 2001 Journal Nature Section Abstract Doc Link 11418861 Disease Relevance 0.22 Pain Relevance 0.64

General Comments

This test has worked.