INT9650

Context Info Confidence 0.75 First Reported 1983 Last Reported 2010 Negated 6 Speculated 6 Reported most in Body Documents 141 Total Number 147 Disease Relevance 104.57 Pain Relevance 29.00

peptidase activity (LPA) transport (LPA) small molecule metabolic process (LPA) extracellular region (LPA) lipid metabolic process (LPA)

Anatomy Link Frequency plasma 17 brain stem 6 midbrain 6 brain 5 platelet 4 LPA (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 492 100.00 Cannabinoid 37 100.00 Neuropathic pain 47 99.68 Angina 212 99.64 Pain 265 99.46 cINOD 31 99.44 IPN 20 99.44 aspirin 168 99.38 midbrain 112 99.08 Neurotransmitter 24 98.96

Disease Link Frequency Relevance Heat Disorder Of Lipid Metabolism 742 100.00 INFLAMMATION 561 100.00 Nicotine Addiction 128 100.00 Pressure And Volume Under Development 115 100.00 Body Weight 78 100.00 Metabolic Syndrome 76 100.00 Hyperhomocysteinemia 39 100.00 Proteinuria 15 100.00 Coronary Artery Disease 534 99.96 Hyperlipidemia 128 99.96

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Anatomy

Negation

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Disease term

Bezafibrate produced significant reductions in LDL-C (-17%), total cholesterol (-13%), LDL-C/HDL-C (-24%), triglycerides (-28%), apo B (-15%), and LpA-I (-10%) and significantly increased HDL-C (+12%), apo A-I (+9%), apo A-II (+30%), apo E (+14%), and Lp(a) (+3%).

Gene_expression (produced) of LpA associated with disorder of lipid metabolism

1) Confidence 0.75 Published 1994 Journal Am. J. Med. Section Abstract Doc Link 8017468 Disease Relevance 1.00 Pain Relevance 0.25

The levels of serum Lp(a), total cholesterol, high density lipoprotein-cholesterol, triglyceride, and remnant lipoprotein cholesterol were determined on admission.

Spec (determined) Gene_expression (levels) of Lp associated with disorder of lipid metabolism

2) Confidence 0.68 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978291 Disease Relevance 1.02 Pain Relevance 0.18

Based on their serum Lp(a) levels, patients were classified into tertiles as follows: Tertile 1 (n=276), Lp(a)<13.8 mg/dL; Tertile 2 (n=279), Lp(a)=13.8-30.6 mg/dL; and Tertile 3 (n=277), Lp(a)?

Gene_expression (levels) of Lp

3) Confidence 0.67 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978291 Disease Relevance 1.20 Pain Relevance 0.17

Total cholesterol, low density lipoprotein-cholesterol, and apolipoprotein B levels were adjusted for Lp(a) contribution,10) according to compositional data in which cholesterol accounts for ?

Gene_expression (levels) of apolipoprotein associated with disorder of lipid metabolism

4) Confidence 0.67 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978291 Disease Relevance 0.84 Pain Relevance 0

To test for differences between Lp(a) tertiles, categorical variables were compared using the ?

Gene_expression (tertiles) of Lp

5) Confidence 0.67 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978291 Disease Relevance 0.71 Pain Relevance 0

Several changes were observed at this time point including: ipsilateral dorsal root ganglion (DRG) neurons were labeled by injured neurons marker ATF3; LPA(1) receptor expression in DRG neurons was increased; sural C-fibers were more sensitive to LPA stimuli, and this response could be blocked by LPA receptor and substance P receptor antagonists.

Gene_expression (expression) of LPA in neurons

6) Confidence 0.66 Published 2010 Journal Life Sci. Section Body Doc Link 20553953 Disease Relevance 0.08 Pain Relevance 0

The 113 men with intermittent claudication, in contrast to men without this symptomatology, were older at entry (49 +/- 7 vs 45 +/- 7 years), and had higher systolic pressure (144 +/- 20 vs 136 +/- 16 mmHg) and Lp(a) levels (46 +/- 45 vs 33 +/- 35 mg/dl) (all p < 0.05).

Gene_expression (pressure) of Lp associated with restless leg syndrome

7) Confidence 0.66 Published 1995 Journal Am. J. Cardiol. Section Abstract Doc Link 7778544 Disease Relevance 0.85 Pain Relevance 0.74

The 113 men with intermittent claudication, in contrast to men without this symptomatology, were older at entry (49 +/- 7 vs 45 +/- 7 years), and had higher systolic pressure (144 +/- 20 vs 136 +/- 16 mmHg) and Lp(a) levels (46 +/- 45 vs 33 +/- 35 mg/dl) (all p < 0.05).

Gene_expression (levels) of Lp associated with restless leg syndrome

8) Confidence 0.66 Published 1995 Journal Am. J. Cardiol. Section Abstract Doc Link 7778544 Disease Relevance 0.85 Pain Relevance 0.73

Plasma concentrations of fasting blood glucose, hemoglobin A1c, insulin, triglyceride, apoB/apoA-1 ratio, TNF-?

Gene_expression (ratio) of apoA-1 in Plasma

9) Confidence 0.65 Published 2007 Journal Nutrition Research and Practice Section Body Doc Link PMC2849047 Disease Relevance 1.06 Pain Relevance 0

Plasma concentrations of insulin, total cholesterol, LDL-cholesterol, HDL-cholesterol, leptin and adiponectin were significantly higher in females than in males (p<0.05), however, no differences were found in insulin resistance (KITT), fasting blood glucose, hemoglobin A1c, triglyceride, apoB/apoA-1 ratio, CRP, TNF-?

Gene_expression (ratio) of apoA-1 in blood associated with insulin resistance and disorder of lipid metabolism

10) Confidence 0.65 Published 2007 Journal Nutrition Research and Practice Section Body Doc Link PMC2849047 Disease Relevance 0.81 Pain Relevance 0

Autotaxin is the enzyme responsible for the production of lysophosphatidic acid (LPA) from lysophosphatidyl choline (LPC), and it is up-regulated in many inflammatory conditions, including but not limited to cancer, arthritis, and multiple sclerosis.

Gene_expression (production) of LPA associated with multiple sclerosis, inflammation, cancer and arthritis

11) Confidence 0.65 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20392816 Disease Relevance 0.61 Pain Relevance 0.26

Autotaxin's role in producing LPA in plasma and at the site of inflammation was tested in a rat air pouch model.

Gene_expression (producing) of LPA in plasma associated with inflammation

12) Confidence 0.65 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20392816 Disease Relevance 0.92 Pain Relevance 0.51

Collectively, the association of parental history of premature heart attack appears associated with levels of Lp(a) > 30 mg/dl, may lend support to the theory of genetic underpinning for the higher levels of Lp(a) observed in black children.

Gene_expression (levels) of Lp in heart associated with myocardial infarction

13) Confidence 0.64 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC544891 Disease Relevance 1.17 Pain Relevance 0.05

Predictors or independent variables were: gender, age, BMI, smoking, diabetes, hypertension, hypercholesterolemia, Lp(a) levels and apo(a) phenotypes.

Gene_expression (levels) of Lp associated with nicotine addiction, diabetes mellitus, hypertension, obesity and hyperlipidemia

14) Confidence 0.63 Published 2003 Journal BMC Cardiovasc Disord Section Body Doc Link PMC327094 Disease Relevance 1.02 Pain Relevance 0

In our study we found that Lp(a) plasma levels do not seem to show significant differences between the whole group of overweight and normal weight controls.

Gene_expression (levels) of Lp in plasma associated with overweight

15) Confidence 0.63 Published 2003 Journal BMC Cardiovasc Disord Section Body Doc Link PMC327094 Disease Relevance 1.27 Pain Relevance 0.04

Therefore, it seems to be worthy of investigation whether Lp(a) levels and apo(a) isoforms are independent risk factors for CHD in overweight subjects.

Gene_expression (levels) of Lp associated with coronary artery disease and overweight

16) Confidence 0.63 Published 2003 Journal BMC Cardiovasc Disord Section Body Doc Link PMC327094 Disease Relevance 1.17 Pain Relevance 0.04

CONCLUSIONS: With the cautions due to the cross-sectional design of the study and the limited statistical power, these results suggest a possible synergistic effect between elevated Lp(a) levels and other pro-atherogenic factors such as smoking on the risk of vascular diseases in older individuals.

Gene_expression (levels) of Lp

17) Confidence 0.63 Published 2001 Journal J Am Geriatr Soc Section Body Doc Link 11207864 Disease Relevance 0 Pain Relevance 0

Lp(a) levels determined by an ELISA method.

Spec (determined) Gene_expression (levels) of Lp

18) Confidence 0.63 Published 2001 Journal J Am Geriatr Soc Section Body Doc Link 11207864 Disease Relevance 0.28 Pain Relevance 0

RESULTS: No association was observed between elevated Lp(a) levels alone and any of the examined vascular diseases (stroke, myocardial infarction, angina, and intermittent claudication).

Gene_expression (levels) of Lp

19) Confidence 0.63 Published 2001 Journal J Am Geriatr Soc Section Body Doc Link 11207864 Disease Relevance 0.27 Pain Relevance 0

Hence, anti-thrombotic therapy targeting LPA production or receptor-mediated signaling may be a novel strategy to prevent thrombus formation.

Gene_expression (production) of LPA associated with thrombosis

20) Confidence 0.62 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996775 Disease Relevance 1.33 Pain Relevance 0.06

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