INT9660

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Context Info
Confidence 0.62
First Reported 1990
Last Reported 2011
Negated 42
Speculated 29
Reported most in Abstract
Documents 363
Total Number 393
Disease Relevance 312.94
Pain Relevance 139.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
macrophage 10
T-cell 10
plasma 8
brain 5
joints 5
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 4046 100.00 Very High Very High Very High
cytokine 3612 100.00 Very High Very High Very High
rheumatoid arthritis 3310 100.00 Very High Very High Very High
spinal inflammation 867 100.00 Very High Very High Very High
methotrexate 752 100.00 Very High Very High Very High
cINOD 471 100.00 Very High Very High Very High
antagonist 375 100.00 Very High Very High Very High
abatacept 305 100.00 Very High Very High Very High
Inflammatory mediators 205 100.00 Very High Very High Very High
Bioavailability 200 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 4718 100.00 Very High Very High Very High
Disease 3956 100.00 Very High Very High Very High
Rheumatoid Arthritis 3571 100.00 Very High Very High Very High
Cancer 2347 100.00 Very High Very High Very High
Low Back Pain 955 100.00 Very High Very High Very High
Apoptosis 845 100.00 Very High Very High Very High
Necrosis 816 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 637 100.00 Very High Very High Very High
Nicotine Addiction 439 100.00 Very High Very High Very High
Injury 421 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Infliximab, a chimeric monoclonal antibody targeting human tumor necrosis factor alpha (TNF), is approved for the treatment of fistulizing CD.
Regulation (targeting) of TNF associated with necrosis, crohn's disease, infliximab and cancer
1) Confidence 0.62 Published 2003 Journal Inflamm. Bowel Dis. Section Abstract Doc Link 12769443 Disease Relevance 1.16 Pain Relevance 0.67
In this article, we address the role of TNF-alpha in diseases such as rheumatoid arthritis, Crohn's disease, psoriasis, and ankylosing spondylitis as well as the drugs used to modulate TNF-alpha.
Regulation (modulate) of TNF-alpha associated with spinal inflammation, psoriasis, crohn's disease, rheumatoid arthritis and disease
2) Confidence 0.62 Published 2005 Journal J Drugs Dermatol Section Abstract Doc Link 15776786 Disease Relevance 0.88 Pain Relevance 0.50
Among the most successful strategies for treatment has been the use of biologic immunotherapies targeting tumor necrosis factor alpha (TNF).
Regulation (targeting) of tumor necrosis factor alpha associated with necrosis and cancer
3) Confidence 0.61 Published 2008 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC2504074 Disease Relevance 0.94 Pain Relevance 0.48
Among the most successful strategies for treatment has been the use of biologic immunotherapies targeting tumor necrosis factor alpha (TNF).
Regulation (targeting) of TNF associated with necrosis and cancer
4) Confidence 0.61 Published 2008 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC2504074 Disease Relevance 0.94 Pain Relevance 0.48
First, we will assume that both molecules equally affect TNF bioavailability so we can explore independently the effects of sTNF versus tmTNF levels.
Regulation (affect) of TNF associated with bioavailability
5) Confidence 0.61 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 0.15 Pain Relevance 0.29
This observation prompts the question: which factors did influence the TNF?
Regulation (influence) of TNF
6) Confidence 0.61 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991021 Disease Relevance 2.00 Pain Relevance 1.48
We hypothesized that a region on rat chromosome 4 known to regulate experimental autoimmune encephalomyelitis, experimental arthritis and experimental autoimmune neuritis harbors a gene regulating central inflammatory molecules, such as TNF.
Regulation (regulating) of TNF associated with multiple sclerosis, inflammation, experimental autoimmune neuritis, experimental arthritis, neuritis and arthritis
7) Confidence 0.60 Published 2010 Journal J. Immunol. Section Abstract Doc Link 20505148 Disease Relevance 1.09 Pain Relevance 0.35
The profound TNF regulation mapped in congenic strains to the macrophage population.
Regulation (regulation) of TNF in macrophage associated with sprains and strains
8) Confidence 0.60 Published 2010 Journal J. Immunol. Section Abstract Doc Link 20505148 Disease Relevance 1.26 Pain Relevance 0.36
Determination of genes and mechanisms involved in this genetically determined TNF regulation will be valuable in understanding disease pathogenesis and aid treatment development.
Spec (determined) Regulation (regulation) of TNF associated with disease
9) Confidence 0.60 Published 2010 Journal J. Immunol. Section Abstract Doc Link 20505148 Disease Relevance 1.18 Pain Relevance 0.31
The expression levels of the majority of genes (>95%) did not vary over time or with exposure to different biomaterials, but a few important genes, such as TNF-alpha, IL-1beta, IL-6, and MIP1alpha, proved to be highly regulated in response to biomaterial exposure.
Regulation (regulated) of TNF-alpha
10) Confidence 0.60 Published 2005 Journal Biomaterials Section Abstract Doc Link 15603788 Disease Relevance 0.11 Pain Relevance 0.03
Arntl2 (aryl hydrocarbon receptor nuclear translocator-like 2) up-regulation correlated with the up-regulation of the ARNT-binding motif containing the Pla2g4a gene, which has recently been described as being protective for the progression of insulitis and autoimmune diabetes in the NOD mouse by regulating the TNF-?
Regulation (regulating) of TNF associated with diabetes mellitus
11) Confidence 0.60 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 1.03 Pain Relevance 0.08
In the same patient population (AoCLF), Rifai and colleagues [30] have also shown that after two treatments, Prometheus did not significantly alter inflammatory cytokine levels (C reactive protein, IL-6, and TNF-?).
Neg (not) Regulation (alter) of TNF associated with inflammation and cytokine
12) Confidence 0.60 Published 2007 Journal Crit Care Section Body Doc Link PMC2206413 Disease Relevance 0.69 Pain Relevance 0.18
The concentrations of MIP-2 and TNF-?
Regulation (concentrations) of TNF
13) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 0.19 Pain Relevance 0.09
To date, resistance exercise has not yet been shown to affect the plasma level of TNF-?
Regulation (affect) of TNF in plasma
14) Confidence 0.60 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3022197 Disease Relevance 1.23 Pain Relevance 0.46
For example, although inhibition of PDE7A with BRL 50481 does not itself affect T cell proliferation or TNF-?
Neg (not) Regulation (affect) of TNF in T cell
15) Confidence 0.60 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0.52 Pain Relevance 0.11
Opiate regulation of IL-1beta and TNF-alpha in cultured human articular chondrocytes.
Regulation (regulation) of TNF-alpha in articular associated with opiate
16) Confidence 0.60 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 15979578 Disease Relevance 0.34 Pain Relevance 0.32
In the prospective cross-sectional clinical study described here, we set out to determine whether comorbid depression might affect the TNF?
Spec (might) Regulation (affect) of TNF associated with depression
17) Confidence 0.53 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991021 Disease Relevance 1.73 Pain Relevance 1.25
Strategies for targeting tumour necrosis factor in IBD.
Regulation (targeting) of tumour necrosis factor associated with inflammatory bowel disease, necrosis and cancer
18) Confidence 0.53 Published 2003 Journal Best Pract Res Clin Gastroenterol Section Title Doc Link 12617886 Disease Relevance 1.75 Pain Relevance 0.51
[Effect of intravenous treatment with tumor necrosis factor alpha in patients with advanced cancer--phase I clinical trials].
Regulation ([Effect) of tumor necrosis factor associated with necrosis, cancer and headache
19) Confidence 0.45 Published 1995 Journal Prz. Lek. Section Title Doc Link 8834840 Disease Relevance 0.85 Pain Relevance 0.17
Though TNF-alpha immunomodulation seems to be a very effective, promising treatment in several TNF-alpha mediated disease processes, long-term studies need to be performed to assess the risk-benefit ratio of using these drugs over an extended period of time.
Regulation (immunomodulation) of TNF-alpha associated with disease
20) Confidence 0.45 Published 2005 Journal J Drugs Dermatol Section Abstract Doc Link 15776786 Disease Relevance 0.82 Pain Relevance 0.42

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