INT96881

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Context Info
Confidence 0.50
First Reported 2001
Last Reported 2005
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 3.27
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ARNT) nucleus (ARNT) transcription factor binding (ARNT)
cytoplasm (ARNT) signal transducer activity (ARNT)
ARNT (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 28 99.60 Very High Very High Very High
Kappa opioid receptor 1 99.36 Very High Very High Very High
agonist 2 97.64 Very High Very High Very High
opioid receptor 4 91.80 High High
Opioid 2 88.60 High High
pain pelvic 7 88.40 High High
Analgesic 1 84.64 Quite High
Disease Link Frequency Relevance Heat
Endometriosis (extended) 28 99.60 Very High Very High Very High
Disease 14 96.44 Very High Very High Very High
Reprotox - General 3 7 88.40 High High
Hypoxia 7 80.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study characterizes the expression of AhR and ARNT mRNA in a human endometrial explant culture model in the absence and presence of TCDD exposure.
Gene_expression (expression) of ARNT mRNA
1) Confidence 0.50 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11452142 Disease Relevance 0.38 Pain Relevance 0.18
Constitutive AhR mRNA expression was donor age dependent (increasing with age), while ARNT mRNA expression was donor age and tissue phase dependent (increased in older and proliferative phase specimens).
Gene_expression (expression) of ARNT mRNA
2) Confidence 0.50 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11452142 Disease Relevance 0.37 Pain Relevance 0.19
The expression of both genes was similar for all individual explants and the ratio of AhR:ARNT mRNA expression across all samples was 1.7 to 1.8.
Gene_expression (expression) of ARNT mRNA
3) Confidence 0.50 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11452142 Disease Relevance 0.47 Pain Relevance 0.22
Expression of AhR and ARNT mRNA in cultured human endometrial explants exposed to TCDD.
Gene_expression (Expression) of ARNT mRNA
4) Confidence 0.50 Published 2001 Journal Toxicol. Sci. Section Title Doc Link 11452142 Disease Relevance 0.41 Pain Relevance 0.19
After culture, AhR and ARNT mRNA expression were quantified by RT-PCR.
Gene_expression (expression) of ARNT mRNA
5) Confidence 0.50 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11452142 Disease Relevance 0.44 Pain Relevance 0.23
TCDD treatment significantly increased the expression of AhR mRNA, but not ARNT mRNA.
Gene_expression (expression) of ARNT mRNA
6) Confidence 0.43 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11452142 Disease Relevance 0.43 Pain Relevance 0.23
Similar to results in the parallel study on expression of CYP1A1 mRNA, CYP1B1 mRNA, EROD activity, and CYP1B1 protein, the presence of endometriosis did not affect the expression of AhR or ARNT mRNA, either constitutively or following TCDD exposure.
Gene_expression (expression) of ARNT mRNA associated with endometriosis
7) Confidence 0.39 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11452142 Disease Relevance 0.38 Pain Relevance 0.17
Expression of subunits of HIF-1, HIF-1alpha, and HIF-1beta were examined by Western blot using specific antibodies.
Spec (examined) Gene_expression (Expression) of HIF-1beta
8) Confidence 0.08 Published 2005 Journal J Anesth Section Abstract Doc Link 16032459 Disease Relevance 0.38 Pain Relevance 0.57

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