INT96883

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Context Info
Confidence 0.70
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.24
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP1B1) endoplasmic reticulum (CYP1B1)
CYP1B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 4 94.36 High High
pain pelvic 1 93.28 High High
anesthesia 6 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
halothane 2 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Dismenorea 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
Rheumatism 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis (extended) 5 94.36 High High
Reprotox - General 3 1 93.28 High High
Glaucoma 184 85.68 High High
Hepatocellular Cancer 1 85.28 High High
Disease 30 70.04 Quite High
Hypoxia 17 52.48 Quite High
Stress 30 51.84 Quite High
Breast Cancer 11 50.00 Quite Low
Apoptosis 30 12.16 Low Low
Ocular Hypertension 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of CYP1A1 and CYP1B1 mRNA was greatest with 10 nM TCDD and increased up to 72 h after initial exposure.
Positive_regulation (increased) of Gene_expression (expression) of CYP1B1 mRNA
1) Confidence 0.70 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11452143 Disease Relevance 0.42 Pain Relevance 0.22
In accordance with Bejjani and coworkers [4] and as mentioned before, we speculate that residual enzymatic activity from hypomorphic alleles in these subjects could be sufficient to maintain the normal phenotype either alone or in cooperation with compensating variants of unknown modifier genes and/or the increased CYP1B1 expression induced by compounds present in the environment and/or the diet.
Positive_regulation (increased) of Gene_expression (expression) of CYP1B1
2) Confidence 0.69 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645906 Disease Relevance 0.31 Pain Relevance 0
The upregulation of CYP1A1 and CYP1B1 expression by extract and purified cycloartanes cannot be explained by AhR binding.
Positive_regulation (upregulation) of Gene_expression (expression) of CYP1B1
3) Confidence 0.47 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.19 Pain Relevance 0
In accordance with Bejjani and coworkers [4] and as mentioned before, we speculate that residual enzymatic activity from hypomorphic alleles in these subjects could be sufficient to maintain the normal phenotype either alone or in cooperation with compensating variants of unknown modifier genes and/or the increased CYP1B1 expression induced by compounds present in the environment and/or the diet.
Positive_regulation (induced) of Gene_expression (expression) of CYP1B1
4) Confidence 0.47 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645906 Disease Relevance 0.31 Pain Relevance 0

General Comments

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