INT96965

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 7
Disease Relevance 4.37
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
osteoblast 3
muscles 1
PLF (Homo sapiens)
Pain Link Frequency Relevance Heat
backache 9 99.32 Very High Very High Very High
cytokine 20 94.92 High High
Inflammation 24 94.52 High High
Pain 5 80.16 Quite High
chemokine 4 25.00 Low Low
imagery 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Low Back Pain 15 99.90 Very High Very High Very High
Osteoporosis 12 99.78 Very High Very High Very High
Adhesions 4 99.20 Very High Very High Very High
Calcification 4 99.16 Very High Very High Very High
INFLAMMATION 20 94.52 High High
Hypersensitivity 8 91.12 High High
Disease 5 87.36 High High
Pressure Volume 2 Under Development 2 80.64 Quite High
Pain 5 80.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There appears to be consistent evidence suggesting that pedicle screw fixation increases the costs and complication rate of PLF.
Positive_regulation (increases) of PLF
1) Confidence 0.49 Published 2005 Journal Journal of neurosurgery. Spine Section Abstract Doc Link 16028740 Disease Relevance 0.25 Pain Relevance 0.17
Fifty-six patients with spondylolytic spondylolisthesis who underwent PLF with PSF (group 1, 35 patients) or who underwent ALIF with PSF (group 2, 21 patients) were studied.
Positive_regulation (underwent) of PLF associated with low back pain
2) Confidence 0.45 Published 2001 Journal Yonsei Med. J. Section Abstract Doc Link 11456398 Disease Relevance 0.60 Pain Relevance 0.12
Therefore, no definitive statement regarding the efficacy of pedicle screw fixation as a means to improve functional outcomes in patients undergoing PLF for chronic low-back pain can be made.
Positive_regulation (undergoing) of PLF associated with backache
3) Confidence 0.40 Published 2005 Journal Journal of neurosurgery. Spine Section Abstract Doc Link 16028740 Disease Relevance 0.25 Pain Relevance 0.17
Increased PLF also promoted cell adhesion in MC3T3-E1 osteoblast-like cell cultures.
Positive_regulation (Increased) of PLF in osteoblast associated with osteoporosis and adhesions
4) Confidence 0.16 Published 2010 Journal J. Cell. Physiol. Section Abstract Doc Link 20458732 Disease Relevance 0.77 Pain Relevance 0.18
Also in primary osteoblast cultures, increased PLF promoted proliferation and differentiation, the latter assessed by measuring Runx2, alkaline phosphatase (ALP) and osteocalcin mRNA levels; ALP activity; as well as calcium deposition and mineralization.
Positive_regulation (increased) of PLF in osteoblast associated with calcification and osteoporosis
5) Confidence 0.12 Published 2010 Journal J. Cell. Physiol. Section Abstract Doc Link 20458732 Disease Relevance 0.79 Pain Relevance 0.20
PLF levels in forelimb bones and flexor digitorum muscles increased significantly in 6-week HRHF animals, increases attenuated by anti-TNFalpha treatment.
Positive_regulation (increased) of PLF in muscles
6) Confidence 0.11 Published 2010 Journal J. Cell. Physiol. Section Abstract Doc Link 20458732 Disease Relevance 0.91 Pain Relevance 0.39
In primary osteoblast cultures, TNFalpha, MIP2 and MIP3a treatment increased PLF levels in a dose dependent manner.
Positive_regulation (increased) of PLF in osteoblast associated with osteoporosis
7) Confidence 0.10 Published 2010 Journal J. Cell. Physiol. Section Abstract Doc Link 20458732 Disease Relevance 0.78 Pain Relevance 0.21

General Comments

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