INT97050

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Context Info
Confidence 0.22
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.28
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Uchl1) intracellular (Uchl1) ligase activity (Uchl1)
response to stress (Uchl1) cytoplasm (Uchl1) cell proliferation (Uchl1)
Anatomy Link Frequency
skin 1
Uchl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 1 98.40 Very High Very High Very High
unmyelinated 1 90.00 High High
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
hyperexcitability 1 5.00 Very Low Very Low Very Low
Neuritis 1 5.00 Very Low Very Low Very Low
glial activation 1 5.00 Very Low Very Low Very Low
Demyelination 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 75 99.40 Very High Very High Very High
Pain 1 98.40 Very High Very High Very High
Congenital Anomalies 4 97.70 Very High Very High Very High
Neurodegenerative Disease 5 97.12 Very High Very High Very High
Ganglion Cysts 6 96.76 Very High Very High Very High
Diabetes Mellitus 5 96.12 Very High Very High Very High
Parkinson's Disease 1 95.40 Very High Very High Very High
Glaucoma 18 87.28 High High
Metabolic Syndrome 1 86.96 High High
Insulin Resistance 3 84.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The current finding that UCH-L1 mRNA levels are decreased with elevated IOP (Figure 10) is consistent with the findings in other neurodegenerative diseases.
Negative_regulation (decreased) of UCH-L1 mRNA associated with neurodegenerative disease and ocular hypertension
1) Confidence 0.22 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.22 Pain Relevance 0
These may be silent clinically or present with burning feet, neurovascular abnormalities, wherein warm, cold, and heat pain thresholds are disturbed in association with impairment in skin blood flow and loss of PGP 9.5 immunostaining nerves in the skin.
Negative_regulation (loss) of PGP 9.5 in skin associated with pain and congenital anomalies
2) Confidence 0.10 Published 2001 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 11460591 Disease Relevance 0.98 Pain Relevance 0.14

General Comments

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