INT97053

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Context Info
Confidence 0.66
First Reported 2001
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.04
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Parp1) nuclear envelope (Parp1) nucleolus (Parp1)
nucleus (Parp1) protein complex (Parp1) transcription factor binding (Parp1)
Anatomy Link Frequency
cleavage 1
Parp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 14 99.06 Very High Very High Very High
dexamethasone 43 98.56 Very High Very High Very High
Inflammatory mediators 3 95.88 Very High Very High Very High
antagonist 1 75.00 Quite High
Inflammation 23 71.44 Quite High
cytokine 10 70.40 Quite High
Analgesic 1 29.96 Quite Low
withdrawal 7 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 117 97.52 Very High Very High Very High
INFLAMMATION 26 95.48 Very High Very High Very High
Hepatotoxicity 2 87.36 High High
Injury 7 86.68 High High
Stress 8 81.36 Quite High
Osteoporosis 27 79.52 Quite High
Death 16 75.00 Quite High
Lung Injury 102 70.88 Quite High
Urological Neuroanatomy 9 51.24 Quite High
Targeted Disruption 2 44.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B-mediated transcription by PARP is dependent on the catalytic activity of the enzyme or its physical presence [10,46-48].
Transcription (transcription) of PARP
1) Confidence 0.66 Published 2008 Journal Crit Care Section Body Doc Link PMC2575597 Disease Relevance 0.65 Pain Relevance 0.27
The effect of AAP on bcl-XL was antagonized and that on p53 was synergized by the PARP-modulator 4-AB as well as NICO, whereas the endonuclease inhibitor CPZ was without effect on either bcl-XL or p53 expression.
Transcription (synergized) of PARP associated with paracetamol
2) Confidence 0.51 Published 2001 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11461765 Disease Relevance 0.60 Pain Relevance 0.87
PARP cleavage, detected by ICC, was almost absent in control cultures but was readily detected in 3% of cells following 6 days of Dex treatment (Fig. 2D), in agreement with TUNEL data (Fig. 2C).
Neg (absent) Transcription (detected) of PARP in cleavage associated with dexamethasone
3) Confidence 0.14 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.80 Pain Relevance 0.29

General Comments

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