INT9729

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Context Info
Confidence 0.42
First Reported 1981
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 1.86
Pain Relevance 4.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (LHB) small molecule metabolic process (LHB) extracellular region (LHB)
cellular nitrogen compound metabolic process (LHB) cell-cell signaling (LHB)
Anatomy Link Frequency
plasma 2
follicle 2
tendon 1
neural 1
LHB (Homo sapiens)
Pain Link Frequency Relevance Heat
Endogenous opioid 3 99.98 Very High Very High Very High
antagonist 14 99.96 Very High Very High Very High
Cluster headache 6 99.84 Very High Very High Very High
agonist 14 99.74 Very High Very High Very High
opiate 5 99.58 Very High Very High Very High
Buprenorphine 6 99.26 Very High Very High Very High
anesthesia 8 98.56 Very High Very High Very High
Clonidine 10 97.92 Very High Very High Very High
Dismenorea 1 96.60 Very High Very High Very High
Opioid 15 95.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cluster Headache 6 99.84 Very High Very High Very High
Galactorrhea 5 96.96 Very High Very High Very High
Dysmenorrhea 1 96.60 Very High Very High Very High
Polycystic Ovary Syndrome 3 94.76 High High
Congenital Anomalies 2 92.76 High High
Hirsutism 2 87.20 High High
Aging 3 81.44 Quite High
Pain 2 79.84 Quite High
Reprotox - General 1 1 78.72 Quite High
Reprotox - General 2 1 75.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: Ultrasound detected different frequencies of LHB tenosynovitis, SSP and ISP tendon ruptures, glenohumeral JE, BC reduction and HE in RA and DSD patients comparisons.
Negative_regulation (reduction) of LHB in tendon
1) Confidence 0.42 Published 2010 Journal Acta Reumatol Port Section Body Doc Link 20505629 Disease Relevance 0 Pain Relevance 0
Buprenorphine, a mixed opiate agonist-antagonist, suppressed plasma luteinizing hormone (LH) and increased prolactin levels after 12 consecutive days of ascending dose administration (0.5-8 mg/day s.c.) in comparison to drug-free control conditions.
Negative_regulation (suppressed) of luteinizing hormone in plasma associated with antagonist, agonist, opiate and buprenorphine
2) Confidence 0.16 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7057390 Disease Relevance 0 Pain Relevance 0.71
Blood was drawn prior and up to 180 min after drug administration for determination of GH, adrenocorticotropic hormone (ACTH), prolactin, thyrotropin (TSH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), glucose, clonidine, and moxonidine concentrations.
Negative_regulation (determination) of luteinizing hormone in follicle associated with clonidine
3) Confidence 0.12 Published 1995 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 7584524 Disease Relevance 0 Pain Relevance 0.70
In an attempt to further define the inhibitory effect of excessive PRL release on luteinizing hormone releasing hormone (LHRH) and luteinizing hormone (LH) secretory patterns in human plasma, four amenorrheic women with known hyperprolactinemia were studied before and during bromocriptine (BRCR) therapy.
Negative_regulation (effect) of luteinizing hormone in plasma associated with galactorrhea
4) Confidence 0.11 Published 1987 Journal J Reprod Med Section Abstract Doc Link 3550065 Disease Relevance 0.38 Pain Relevance 0.14
Both dopaminergic (DA) and noradrenergic (NA) neural systems contribute to the suppression of luteinizing hormone (LH) pulse frequency in intact anestrous ewes.
Negative_regulation (suppression) of luteinizing hormone in neural
5) Confidence 0.09 Published 1989 Journal Neuroendocrinology Section Abstract Doc Link 2812274 Disease Relevance 0 Pain Relevance 0.23
Conversely, TU treatment was associated with a significant decrease in sex hormone–binding globulin, follicular-stimulating hormone, and luteinizing hormone (all p <0.001).
Negative_regulation (decrease) of luteinizing hormone
6) Confidence 0.09 Published 2008 Journal Am J Cardiol Section Body Doc Link PMC2258313 Disease Relevance 0.29 Pain Relevance 0.03
Effects of pentobarbital anesthesia on tonic luteinizing hormone secretion in the ewe: evidence for active inhibition of luteinizing hormone in anestrus.
Negative_regulation (inhibition) of luteinizing hormone associated with anesthesia
7) Confidence 0.07 Published 1984 Journal Biol. Reprod. Section Title Doc Link 6538445 Disease Relevance 0 Pain Relevance 0.35
A stepwise reduction of luteinizing hormone (LH) levels was observed with increasing dosages of E2.
Negative_regulation (reduction) of luteinizing hormone
8) Confidence 0.05 Published 1991 Journal Fertil. Steril. Section Abstract Doc Link 2010000 Disease Relevance 0 Pain Relevance 0.41
In the ewe, seasonal anestrus appears to result from two effects of inhibitory photoperiod: 1) estradiol gains the capacity to suppress luteinizing hormone (LH) pulse frequency and hence becomes a potent inhibitor of tonic LH secretion and 2) a steroid-independent decrease in LH pulse frequency occurs in ovariectomized ewes.
Negative_regulation (suppress) of luteinizing hormone
9) Confidence 0.05 Published 1984 Journal Biol. Reprod. Section Abstract Doc Link 6538445 Disease Relevance 0 Pain Relevance 0.22
Endotoxin inhibition of luteinizing hormone in sheep.
Negative_regulation (inhibition) of luteinizing hormone
10) Confidence 0.05 Published 2003 Journal Domest. Anim. Endocrinol. Section Title Doc Link 12963096 Disease Relevance 0.07 Pain Relevance 0.13
Endogenous opioid suppression of luteinizing hormone pulse frequency and amplitude in the ewe: hypothalamic sites of action.
Negative_regulation (suppression) of luteinizing hormone associated with endogenous opioid
11) Confidence 0.03 Published 1991 Journal Neuroendocrinology Section Title Doc Link 1784345 Disease Relevance 0 Pain Relevance 0.23
A significant decrease in luteinizing hormone (LH) and testosterone levels (70 and 40%, respectively) was apparent after 3 months.
Negative_regulation (decrease) of luteinizing hormone
12) Confidence 0.03 Published 1981 Journal Obstet Gynecol Section Abstract Doc Link 6454866 Disease Relevance 0.63 Pain Relevance 0.08
Concentrations of cortisol and progesterone increased (P < 0.05) following LPS injections in both groups II and III, whereas luteinizing hormone (LH) concentrations were suppressed (P < 0.05).
Negative_regulation (suppressed) of luteinizing hormone
13) Confidence 0.03 Published 1995 Journal Reprod. Toxicol. Section Abstract Doc Link 7795327 Disease Relevance 0 Pain Relevance 0.42
Total, free and carrier protein-bound testosterone levels were significantly diminished only in chronic CH, where luteinizing hormone (LH) peak values after intravenous administration of LHRH were also decreased.
Negative_regulation (decreased) of luteinizing hormone associated with cluster headache
14) Confidence 0.02 Published 1989 Journal Cephalalgia Section Abstract Doc Link 2663174 Disease Relevance 0.44 Pain Relevance 0.53
The aim of this study was to determine whether the decline in oestradiol inhibition of circulating luteinizing hormone (LH) and follicle-stimulating hormone (FSH) during the peripubertal period of heifers is associated with a change in opioid modulation of LH and FSH secretion.
Spec (whether) Negative_regulation (inhibition) of luteinizing hormone in follicle associated with opioid
15) Confidence 0.02 Published 1992 Journal J. Reprod. Fertil. Section Abstract Doc Link 1432947 Disease Relevance 0.06 Pain Relevance 0.45

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