INT97308

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Context Info
Confidence 0.65
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 13.26
Pain Relevance 2.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (TPO) oxidoreductase activity (TPO) plasma membrane (TPO)
cellular nitrogen compound metabolic process (TPO) cytoplasm (TPO)
Anatomy Link Frequency
thyroid 4
combs 1
autonomic 1
PSP 1
kidney 1
TPO (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 8 99.80 Very High Very High Very High
Peripheral nervous system 1 99.22 Very High Very High Very High
peripheral neuropathy 3 95.68 Very High Very High Very High
conotoxin 20 94.72 High High
lidocaine 4 94.00 High High
dysesthesia 1 93.12 High High
Demyelination 3 89.20 High High
corticosteroid 73 88.96 High High
Crohn's disease 5 87.92 High High
Infliximab 81 87.44 High High
Disease Link Frequency Relevance Heat
Multiple System Atrophy 33 100.00 Very High Very High Very High
Cancer 15 99.84 Very High Very High Very High
Death 10 99.84 Very High Very High Very High
Celiac Disease 65 99.80 Very High Very High Very High
Pain 4 99.80 Very High Very High Very High
Supranuclear Palsy 10 99.76 Very High Very High Very High
Sudden Death 4 99.10 Very High Very High Very High
Peripheral Neuropathy 4 98.88 Very High Very High Very High
Encephalopathy 46 98.72 Very High Very High Very High
Thyroiditis 57 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thyroid peroxidase antibodies were negative in eight patients tested; none had a family history of autoimmune thyroid disease.
Neg (negative) Gene_expression (negative) of Thyroid peroxidase in thyroid associated with thyroid disease
1) Confidence 0.65 Published 2001 Journal Thyroid Section Abstract Doc Link 11484899 Disease Relevance 0.52 Pain Relevance 0.10
Common features are high anti-thyroid peroxidase antibody titres, an abnormal EEG and an elevated CSF protein concentration.
Gene_expression (titres) of thyroid peroxidase in thyroid
2) Confidence 0.65 Published 2004 Journal Scott Med J Section Abstract Doc Link 15648714 Disease Relevance 0.62 Pain Relevance 0.04
Main outcome measures included thyrotropin, thyroxine (T(4)), free thyroxine, triiodothyronine (T(3)), anti-thyroid peroxidase antibodies, and Hamilton depression (HAM-D) rating scale.
Gene_expression (antibodies) of thyroid peroxidase in thyroid
3) Confidence 0.65 Published 2009 Journal Thyroid Section Body Doc Link 19583486 Disease Relevance 0.29 Pain Relevance 0
We detected ANA in 5 of 61 patients (8.2%), ASMA in 8 of 52 patients (7.4%), anti-Tg or anti-TPO in 9 of 104 patients (8.6%), and positive direct combs in 1 of 48 patients (2%), whereas anti-dsDNA, AMA and LKM-1 were not detected in any patients.
Gene_expression (detected) of TPO in combs
4) Confidence 0.55 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2768234 Disease Relevance 1.10 Pain Relevance 0
The authors postulate that peripheral nervous system impairment can anticipate the typical appearance of MSA, and they suggest that, in peripheral neuropathies with autonomic system dysfunction, after excluding main causes of autonomic neuropathy, MSA may need to be suspected.
Gene_expression (appearance) of MSA in autonomic associated with peripheral nervous system, peripheral neuropathy, multiple system atrophy and diabetic nephropathy
5) Confidence 0.53 Published 2001 Journal Clin. Auton. Res. Section Abstract Doc Link 11570601 Disease Relevance 0.99 Pain Relevance 0.23
Our analyses also demonstrated that nocturnal sudden death was the most frequent cause of death in our MSA cohort, and CPAP could not be a prophylactic measure against sudden death.
Gene_expression (cohort) of MSA associated with multiple system atrophy, death and sudden death
6) Confidence 0.24 Published 2009 Journal Rinsho Shinkeigaku Section Abstract Doc Link 19594101 Disease Relevance 1.46 Pain Relevance 0.08
Anti-thyroperoxidase (TPO) and anti-thyroglobulin (TG) Abs have been often detected in the CSF of EAATD patients but their possible role in the pathogenesis has been not defined [2].
Gene_expression (detected) of TPO
7) Confidence 0.15 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2876143 Disease Relevance 0.93 Pain Relevance 0.12
In the CSF, anti-TPO and anti-TG Abs were positive in 5/5 (Patient 2, 6, 7, 10, and 14) and 2/2 (Patient 6 and 7) cases, respectively.
Gene_expression (positive) of TPO
8) Confidence 0.15 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2876143 Disease Relevance 0.70 Pain Relevance 0.12
Anti-thyroperoxidase (TPO) and anti-thyroglobulin (TG) Abs have been often detected in the CSF of EAATD patients but their possible role in the pathogenesis has been not defined [2].
Gene_expression (detected) of Anti-thyroperoxidase
9) Confidence 0.15 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2876143 Disease Relevance 0.99 Pain Relevance 0.13
Pain was more problematic in MSA than PSP.
Gene_expression (problematic) of MSA in PSP associated with pain, supranuclear palsy and multiple system atrophy
10) Confidence 0.14 Published 2010 Journal Mov. Disord. Section Abstract Doc Link 20535826 Disease Relevance 2.59 Pain Relevance 0.33
It is quite interesting to note that, among the large spectrum of cardiotoxic drugs, the authors of the experimental studies selected only drugs having MSA.
Gene_expression (having) of MSA associated with multiple system atrophy
11) Confidence 0.11 Published 2007 Journal Crit Care Section Body Doc Link PMC2206443 Disease Relevance 0.44 Pain Relevance 0.36
Antithyroper-oxidase antibodies (anti-TPO) were highly elevated and thyroid function tests had evidenced a clinically significant hypothyroidism.
Gene_expression (elevated) of anti-TPO in thyroid associated with thyroid disease
12) Confidence 0.08 Published 2008 Journal Panminerva Med Section Abstract Doc Link 18927530 Disease Relevance 1.76 Pain Relevance 0.17
There have been a number of trials of new materials or therapeutic methods which have already turned out to be ineffective or too toxic to clinically apply, such as exogenous interleukin-6, transfection of human thyroperoxidase gene in tumor cells, and imatineb mesylate monotherapy.24 In recent studies, some trials were partially successful or promising in vitro or vivo.
Gene_expression (transfection) of thyroperoxidase gene associated with cancer
13) Confidence 0.07 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2810588 Disease Relevance 0.37 Pain Relevance 0
Note that sequences presented in the MSA include all six conserved cysteines (as opposed to four cysteines in PF08087, Fig. 6, bottom).
Gene_expression (presented) of MSA associated with multiple system atrophy
14) Confidence 0.06 Published 2010 Journal Bioinformatics Section Body Doc Link PMC2935411 Disease Relevance 0.40 Pain Relevance 0.31
Detection of anti-smooth muscle (SMA), anti-mitochondrial (AMA), anti-liver kidney microsomes (LKM), anti-thyroid peroxidase (TPO), anti-thyroglobulin (TG) and anti-adrenal (ADA) autoantibodies
Gene_expression (Detection) of thyroid peroxidase in kidney
15) Confidence 0.04 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064868 Disease Relevance 0.08 Pain Relevance 0.12

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