INT97473

Context Info Confidence 0.34 First Reported 2001 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.72 Pain Relevance 0.18

peptidase activity (FAP) extracellular space (FAP) plasma membrane (FAP)

Anatomy Link Frequency germline 1 epithelium 1 FAP (Homo sapiens)

Pain Link Frequency Relevance Heat Anterior cingulate cortex 81 88.16 Action potential 9 71.92 antagonist 8 65.96 Glutamate receptor 3 65.52 conotoxin 3 61.20 Anterior cingulate 1 50.00 depression 10 13.60 COX2 2 10.00 cOX1 1 10.00 Thalamus 30 5.00

Disease Link Frequency Relevance Heat Familial Adenomatous Polyposis 54 100.00 Adenoma 33 95.28 Polyps 35 91.76 Cancer 183 88.08 Adenomatous Polyps 6 85.52 Colorectal Cancer 50 73.24 Intestinal Polyposis 1 63.56 Syndrome 44 60.12 Disease 46 55.84 INFLAMMATION 4 54.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

One of the first alleged CFS families was later shown to have an attenuated variant of FAP.44

Positive_regulation (variant) of FAP associated with familial adenomatous polyposis

1) Confidence 0.34 Published 2006 Journal Medical History Section Body Doc Link PMC1483189 Disease Relevance 0.59 Pain Relevance 0

FAP is caused by germline mutations in the APC (adenomatous polyposis coli) gene.

Positive_regulation (caused) of FAP in germline associated with familial adenomatous polyposis

2) Confidence 0.20 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 2.02 Pain Relevance 0

These findings suggest that the first fAP was directly activated by stimulation without synaptic relay and the second fPSP resulted from postsynaptic excitation.

Positive_regulation (activated) of fAP

3) Confidence 0.17 Published 2009 Journal Mol Pain Section Body Doc Link PMC2745374 Disease Relevance 0 Pain Relevance 0.18

CONCLUSIONS: COX-2 expression is upregulated in the adenomatous epithelium of SAP and FAP, while the COX-1 isoform appears to be constitutively expressed at low levels in both neoplastic and non-neoplastic regions.

Positive_regulation (upregulated) of FAP in epithelium

4) Confidence 0.13 Published 2001 Journal Scand. J. Gastroenterol. Section Body Doc Link 11495083 Disease Relevance 0.11 Pain Relevance 0

General Comments

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