INT97479

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Context Info
Confidence 0.52
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 3.66
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
sensory neurons 2
uterus 1
immune cells 1
spinal cord 1
motor neurons 1
Tks (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 8 99.22 Very High Very High Very High
nociceptor 4 98.88 Very High Very High Very High
Inflammation 68 98.56 Very High Very High Very High
antagonist 18 98.00 Very High Very High Very High
bradykinin 2 97.00 Very High Very High Very High
Spinal cord 6 91.84 High High
substance P 66 80.80 Quite High
Central nervous system 8 75.92 Quite High
spastic colon 12 75.00 Quite High
Peripheral nervous system 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Non-small-cell Lung Cancer 64 99.60 Very High Very High Very High
INFLAMMATION 72 98.56 Very High Very High Very High
Emergencies 2 98.32 Very High Very High Very High
Cancer 71 98.20 Very High Very High Very High
Colon Cancer 2 95.44 Very High Very High Very High
Neurogenic Inflammation 4 94.72 High High
Breast Cancer 2 92.32 High High
Increased Venous Pressure Under Development 4 92.16 High High
Nociception 2 80.64 Quite High
Bladder Disease 6 79.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following chronic inflammation, both immune cells and capsaicin-resistant sensory neurons can de novo express TKs: whether these pools of TKs are releasable and contribute to inflammatory processes is presently unsettled.
Gene_expression (express) of TKs in sensory neurons associated with qutenza and inflammation
1) Confidence 0.52 Published 2001 Journal Regul. Pept. Section Abstract Doc Link 11495674 Disease Relevance 0.73 Pain Relevance 0.63
In the normal urinary bladder, tachykinins (TKs) are expressed in a population of bladder nociceptors that is sensitive to the excitatory and desensitizing effects of capsaicin (i.e., capsaicin-sensitive primary afferent neurons (CSPANs)).
Gene_expression (expressed) of TKs in afferent neurons associated with qutenza and nociceptor
2) Confidence 0.52 Published 2001 Journal Regul. Pept. Section Abstract Doc Link 11495674 Disease Relevance 0.27 Pain Relevance 0.48
We have previously found that all genes encoding TKs and their receptors are expressed in the mammalian uteri and that their expression and function vary during the ovarian cycle, throughout pregnancy and with age, [3,10,29,30,38,39].
Gene_expression (expressed) of TKs
3) Confidence 0.44 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0.11
Tachykinins (TKs) are abundantly expressed in the gastrointestinal (GI) tract in intrinsic excitatory motor neurons, interneurons, sensory neurons and extrinsic sensory neurons.
Gene_expression (expressed) of TKs in sensory neurons
4) Confidence 0.39 Published 2002 Journal Curr Opin Investig Drugs Section Abstract Doc Link 12090730 Disease Relevance 0.20 Pain Relevance 0.15
Indeed, little is known about the physiological mechanisms that regulate the expression of TKs and their receptors in mouse uterus and in particular the influence of ovarian steroids upon their expression.
Gene_expression (expression) of TKs in uterus
5) Confidence 0.39 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0.07
The most studied effects produced by TKs in these systems are smooth muscle contraction [5-9], modulation of inflammation [10,11], mucus secretion, and recruitment/activation of immune cells [12].
Gene_expression (produced) of TKs in immune cells associated with inflammation
6) Confidence 0.36 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.37 Pain Relevance 0.20
In the urinary tract, the major recognized sources of TKs are the primary afferent neurons expressing transient receptor potential vanilloid-1 receptors, which have the unique property of releasing transmitters both in the periphery (efferent function) and the spinal cord (afferent function) upon stimulation [2].
Gene_expression (sources) of TKs in spinal cord associated with spinal cord
7) Confidence 0.32 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.61 Pain Relevance 0.51
For example, cetuximab and trastuzumab bind to the EGFR and HER-2/neu receptor TKs respectively; these molecules are often overexpressed in colorectal (EGFR) and breast (HER-2/neu) cancers and the efficacy of cetuximab in the treatment of metastatic colorectal cancer (Cunningham et al 2004) and trastuzumab in the treatment of breast cancer (Slamon et al 2001; Piccart-Gebhart et al 2005; Romond et al 2005) has been demonstrated clearly.
Gene_expression (overexpressed) of TKs associated with cancer, breast cancer and colon cancer
8) Confidence 0.26 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661649 Disease Relevance 0.75 Pain Relevance 0
Tachykinins (TKs) are abundantly expressed in the gastrointestinal (GI) tract in intrinsic excitatory motor neurons, interneurons, sensory neurons and extrinsic sensory neurons.
Gene_expression (expressed) of TKs in motor neurons
9) Confidence 0.13 Published 2002 Journal Curr Opin Investig Drugs Section Abstract Doc Link 12090730 Disease Relevance 0.20 Pain Relevance 0.15
Tachykinins (TKs) are abundantly expressed in the gastrointestinal (GI) tract in intrinsic excitatory motor neurons, interneurons, sensory neurons and extrinsic sensory neurons.
Gene_expression (expressed) of TKs in interneurons
10) Confidence 0.13 Published 2002 Journal Curr Opin Investig Drugs Section Abstract Doc Link 12090730 Disease Relevance 0.20 Pain Relevance 0.15
The EGFR family of TKs, referred to as the HER/ErbB family, consists of 4 members-EGFR (HER1/ErbB1), HER2 (ErbB2), HER3 (ErbB3) and HER4 (ErbB4)-that regulate many developmental, metabolic and physiological processes.
Gene_expression (family) of TKs
11) Confidence 0.06 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004579 Disease Relevance 0.34 Pain Relevance 0

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