INT9749

Context Info Confidence 0.50 First Reported 1992 Last Reported 2010 Negated 1 Speculated 2 Reported most in Abstract Documents 25 Total Number 26 Disease Relevance 9.96 Pain Relevance 2.09

Anatomy Link Frequency sting 6 pollen 4 lung 2 nerve 1 edges 1 sar (Mus musculus)

Pain Link Frequency Relevance Heat syringomyelia 82 98.86 Antihistamine 8 98.84 vagus nerve 10 97.80 c fibre 16 97.28 imagery 18 84.28 potassium channel 2 75.00 Inflammatory mediators 1 61.72 Pain 30 61.28 headache 10 30.00 anesthesia 7 25.00

Disease Link Frequency Relevance Heat Hypersensitivity 464 100.00 Rhinitis 20 99.98 Bites And Stings 200 99.84 Syringomyelia 82 98.86 Abnormal Reflex 17 96.40 Scoliosis 98 89.52 Cancer 1 87.36 Insect Bites And Stings 56 75.00 Fever 3 75.00 Paralysis 1 74.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

If patients without any indicators of syringomyelia were regarded as genuine "idiopathic" cases, this might increase the PPV of SAR.

Spec (might) Positive_regulation (increase) of SAR associated with syringomyelia

1) Confidence 0.50 Published 2010 Journal Scoliosis Section Body Doc Link PMC2939502 Disease Relevance 1.11 Pain Relevance 0.34

We used the information about the prevalence of symptoms, calling time per day, and number of calls per day and combined it with measurements of the Specific Absorption Rate (SAR).

Positive_regulation (measurements) of SAR

2) Confidence 0.49 Published 2003 Journal Bioelectromagnetics Section Abstract Doc Link 12669297 Disease Relevance 0 Pain Relevance 0

Intravenous administration of 4-aminopyridine (0. 7 and 2.0 mg/kg i.v.), a K(+) channel blocker, which dose-dependently increased SAR activity during deflation and had no effect on P(T), abolished or attenuated the decrease in SAR activities induced by CO(2) inhalation in a dose-dependent manner.

Positive_regulation (increased) of SAR

3) Confidence 0.45 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10454467 Disease Relevance 0 Pain Relevance 0.08

Absorbers can induce a significant increase of SAR in muscle and fat near their edges.

Positive_regulation (increase) of SAR in edges

4) Confidence 0.32 Published 2001 Journal Int J Hyperthermia Section Abstract Doc Link 11347729 Disease Relevance 0.35 Pain Relevance 0.06

We investigated the safety and efficacy of omalizumab in the treatment of patients with Japanese cedar pollen-induced SAR compared to placebo.

Positive_regulation (induced) of SAR in pollen associated with rhinitis

5) Confidence 0.32 Published 2006 Journal Allergol Int Section Abstract Doc Link 17130680 Disease Relevance 0.44 Pain Relevance 0

Intravenous administration of 4-aminopyridine (0. 7 and 2.0 mg/kg i.v.), a K(+) channel blocker, which dose-dependently increased SAR activity during deflation and had no effect on P(T), abolished or attenuated the decrease in SAR activities induced by CO(2) inhalation in a dose-dependent manner.

Positive_regulation (induced) of SAR

6) Confidence 0.30 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10454467 Disease Relevance 0 Pain Relevance 0.07

Administration of ouabain (50 microg/kg) initially stimulated SAR activity during both inflation and deflation, but after 20 min, two different types of SAR responses were observed; one became silent at the peak, of inflation only, and the other maintained excitatory activity during both inflation and deflation phases.

Positive_regulation (stimulated) of SAR

7) Confidence 0.26 Published 1998 Journal Life Sci. Section Abstract Doc Link 9952289 Disease Relevance 0 Pain Relevance 0.05

METHODS: A randomized, placebo-controlled, double-blind study was conducted in 100 Japanese patients with a history of moderate-to-severe SAR induced by Japanese cedar pollens.

Positive_regulation (induced) of SAR in pollens

8) Confidence 0.19 Published 2006 Journal Allergol Int Section Body Doc Link 17130680 Disease Relevance 0.09 Pain Relevance 0

CONCLUSIONS: Omalizumab was effective and safe in the treatment of SAR induced by Japanese cedar pollen.

Positive_regulation (induced) of SAR in pollen

9) Confidence 0.19 Published 2006 Journal Allergol Int Section Body Doc Link 17130680 Disease Relevance 0 Pain Relevance 0

BACKGROUND: Seasonal allergic rhinitis (SAR) induced by Japanese cedar pollen is a substantial problem in Japan.

Positive_regulation (induced) of SAR in pollen associated with rhinitis

10) Confidence 0.19 Published 2006 Journal Allergol Int Section Abstract Doc Link 17130680 Disease Relevance 0.36 Pain Relevance 0

Increased risk of experiencing SAR to a future sting in wasp allergic patients after cessation of adequate IT was significantly associated with a SAR due to IT during the rush regimen.

Positive_regulation (Increased) of SAR in sting associated with bites and stings and hypersensitivity

11) Confidence 0.17 Published 2005 Journal Clin Mol Allergy Section Abstract Doc Link PMC1208928 Disease Relevance 1.08 Pain Relevance 0

That means that the untreated patient would expect SAR to several future stings.

Positive_regulation (expect) of SAR in stings associated with bites and stings and hypersensitivity

12) Confidence 0.17 Published 2005 Journal Clin Mol Allergy Section Body Doc Link PMC1208928 Disease Relevance 0.37 Pain Relevance 0

According to other studies the following symptoms and signs have been found to be risk factors for experiencing SAR at a future sting after cessation of adequate IT [13]: severity of pre-treatment reaction, safety and efficacy of IT, duration of IT, and high sensitivity with the IC test.

Positive_regulation (experiencing) of SAR in sting associated with bites and stings and hypersensitivity

13) Confidence 0.17 Published 2005 Journal Clin Mol Allergy Section Body Doc Link PMC1208928 Disease Relevance 0.77 Pain Relevance 0

However, the adequately treated wasp allergic patients experienced a SAR to sting after cessation of IT more frequently than has been found in other studies [12].

Positive_regulation (experienced) of SAR in sting associated with bites and stings and hypersensitivity

14) Confidence 0.17 Published 2005 Journal Clin Mol Allergy Section Body Doc Link PMC1208928 Disease Relevance 0.78 Pain Relevance 0

The percentage of patients experiencing a SAR during incremental dosing is higher.

Positive_regulation (experiencing) of SAR associated with hypersensitivity

15) Confidence 0.17 Published 2005 Journal Clin Mol Allergy Section Body Doc Link PMC1208928 Disease Relevance 0.16 Pain Relevance 0.05

Increased risk of experiencing SAR to a future sting in wasp allergic patients after cessation of adequate IT was significantly associated with a SAR due to IT during the rush regimen.

Positive_regulation (experiencing) of SAR in sting associated with bites and stings and hypersensitivity

16) Confidence 0.17 Published 2005 Journal Clin Mol Allergy Section Abstract Doc Link PMC1208928 Disease Relevance 1.08 Pain Relevance 0

None of the bee allergic patients experienced a SAR after cessation of IT.

Positive_regulation (experienced) of SAR associated with hypersensitivity

17) Confidence 0.17 Published 2005 Journal Clin Mol Allergy Section Body Doc Link PMC1208928 Disease Relevance 1.69 Pain Relevance 0

Table 11 lists a comparison between those who did not experience any reaction to a sting after cessation of adequate IT (group A) and those who experienced a SAR (group B) in patients allergic to common wasp.

Positive_regulation (experienced) of SAR in sting associated with bites and stings and hypersensitivity

18) Confidence 0.17 Published 2005 Journal Clin Mol Allergy Section Body Doc Link PMC1208928 Disease Relevance 1.45 Pain Relevance 0

Administration of veratridine (40 microg/kg) stimulated SAR activity but did not significantly alter tracheal pressure.

Neg (not) Positive_regulation (stimulated) of SAR

19) Confidence 0.17 Published 1998 Journal Life Sci. Section Abstract Doc Link 9952289 Disease Relevance 0 Pain Relevance 0.05

Intravenous administration of veratridine (50 microg/kg), an Na(+) channel opener, stimulated deflationary SAR activity: one maintained excitatory activity mainly during deflation and the other receptors showed a tonic discharge during both deflation and inflation.

Positive_regulation (stimulated) of SAR

20) Confidence 0.05 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11805222 Disease Relevance 0 Pain Relevance 0

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