INT9752

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Context Info
Confidence 0.44
First Reported 1990
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 0.36
Pain Relevance 2.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Crhr1) response to stress (Crhr1) signal transducer activity (Crhr1)
Anatomy Link Frequency
hypothalamus 2
face 2
body 2
Crhr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
lidocaine 14 100.00 Very High Very High Very High
tetrodotoxin 8 100.00 Very High Very High Very High
sodium channel 2 100.00 Very High Very High Very High
gABA 2 99.40 Very High Very High Very High
dexamethasone 2 99.04 Very High Very High Very High
halothane 2 95.80 Very High Very High Very High
anesthesia 3 95.40 Very High Very High Very High
Hippocampus 1 94.84 High High
cerebral cortex 1 94.32 High High
medulla 1 90.44 High High
Disease Link Frequency Relevance Heat
Nociception 1 100.00 Very High Very High Very High
Body Weight 1 99.84 Very High Very High Very High
Convulsion 4 80.28 Quite High
Disease 3 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 1 5.00 Very Low Very Low Very Low
Gliosis 1 5.00 Very Low Very Low Very Low
Drug Dependence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of noxious and non-noxious mechanical stimulation of various segmental skin areas (face, forelimb and forepaw, abdomen, hindlimb and hindpaw) on the secretion of immunoreactive corticotropin-releasing hormone (iCRH) from the hypothalamus into hypophysial portal blood was examined in artificially ventilated rats under halothane anesthesia.
Spec (examined) Regulation (effects) of in hypothalamus Localization (secretion) of immunoreactive corticotropin-releasing hormone in face associated with anesthesia and halothane
1) Confidence 0.44 Published 1992 Journal Jpn. J. Physiol. Section Abstract Doc Link 1434108 Disease Relevance 0 Pain Relevance 0.14
The effects of noxious and non-noxious mechanical stimulation of various segmental skin areas (face, forelimb and forepaw, abdomen, hindlimb and hindpaw) on the secretion of immunoreactive corticotropin-releasing hormone (iCRH) from the hypothalamus into hypophysial portal blood was examined in artificially ventilated rats under halothane anesthesia.
Spec (examined) Regulation (effects) of in hypothalamus Localization (secretion) of iCRH in face associated with anesthesia and halothane
2) Confidence 0.44 Published 1992 Journal Jpn. J. Physiol. Section Abstract Doc Link 1434108 Disease Relevance 0 Pain Relevance 0.14
NMU has also been reported to participate in several physiological functions including release of corticotrophin releasing hormone, excitation of nociceptive neurons, and regulation of body weight [62], [63].
Regulation (regulation) of Localization (release) of corticotrophin releasing hormone in body associated with nociception and body weight
3) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0.20 Pain Relevance 0.48
To accomplish this, we first explored the effect of the sodium channel blocker tetrodotoxin (TTX) on basal and stimulated immunoreactive CRH (iCRH) secretion by explanted rat hypothalami.
Regulation (effect) of Localization (secretion) of iCRH associated with tetrodotoxin and sodium channel
4) Confidence 0.12 Published 1990 Journal Horm. Metab. Res. Section Abstract Doc Link 1968416 Disease Relevance 0.16 Pain Relevance 1.09
Verapamil and blockade of serotonergic, alpha-adrenergic and cholinergic receptors did not inhibit the effects of procaine or lidocaine on iCRH secretion, whereas both GABA and dexamethasone exerted inhibitory effects.
Regulation (effects) of Localization (secretion) of iCRH associated with gaba, dexamethasone and lidocaine
5) Confidence 0.05 Published 1990 Journal Horm. Metab. Res. Section Abstract Doc Link 1968416 Disease Relevance 0 Pain Relevance 0.96

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