INT97606

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.24
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cdkn1a) nucleus (Cdkn1a) cell cycle (Cdkn1a)
kinase activity (Cdkn1a) cytoplasm (Cdkn1a)
Anatomy Link Frequency
4T1 1
Cdkn1a (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 55 98.88 Very High Very High Very High
withdrawal 1 93.60 High High
cINOD 3 79.68 Quite High
Inflammation 53 79.04 Quite High
trigeminal ganglion 1 71.44 Quite High
cytokine 33 50.20 Quite High
chemokine 5 41.36 Quite Low
metalloproteinase 4 22.84 Low Low
imagery 12 5.00 Very Low Very Low Very Low
Spinal cord 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 310 100.00 Very High Very High Very High
Repression 7 100.00 Very High Very High Very High
Intestinal Cancer 1 99.04 Very High Very High Very High
Ganglion Cysts 58 98.88 Very High Very High Very High
Apoptosis 55 93.88 High High
Skin Cancer 8 91.92 High High
Neurodegenerative Disease 4 91.20 High High
Bladder Cancer 1 88.80 High High
Death 14 87.52 High High
Infection 32 84.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In Apc1638(+/-) mice, targeted inactivation of p21 increased intestinal tumor formation in a gene-dose-dependent manner, but inactivation of p21 completely eliminated the ability of sulindac to both inhibit mitotic activity in the duodenal mucosa and to inhibit Apc-initiated tumor formation.
Negative_regulation (inactivation) of p21 associated with cancer and intestinal cancer
1) Confidence 0.43 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11507085 Disease Relevance 0.36 Pain Relevance 0.08
Runx1 drives the cell cycle in ORN progenitors through transcription repression of the cyclin dependent kinase inhibitor p21 [23].
Negative_regulation (repression) of p21 associated with repression
2) Confidence 0.35 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 1.15 Pain Relevance 0.22
Finally, 4T1 displayed significantly reduced levels of CDK2-associated protein 1 (CDK2ap1), p53 and two p53 targets, cyclin-dependent kinase inhibitor p21 (Cdkn1a) and cyclin G (Ccng1) (Fig. 11C).
Negative_regulation (inhibitor) of Cdkn1a in 4T1
3) Confidence 0.22 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.31 Pain Relevance 0.03
However, Stat3 promotes proliferation primarily by stimulating transcription of cyclinB1, cdc2, c-myc and cyclinD1 [55,65,66], along with the induction of the immediate early genes c-jun and c-fos [67] and repression of the cell cycle inhibitor p21 [68].
Negative_regulation (repression) of p21 associated with repression
4) Confidence 0.17 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.17 Pain Relevance 0.04
G1 cell cycle arrest is, in most cases, a result of the induction of the CDKN1A gene, which encodes the cyclin-dependent kinase inhibitor WAF1 (also known as p21; Richon et al. 2000).
Negative_regulation (inhibitor) of WAF1
5) Confidence 0.14 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 0.30 Pain Relevance 0
Cells deficient in p21 are unable to maintain stability of the cycle arrest [89].
Negative_regulation (deficient) of p21
6) Confidence 0.02 Published 2008 Journal Parasit Vectors Section Body Doc Link PMC2538513 Disease Relevance 0.45 Pain Relevance 0.05
It has been shown that HDACs inhibitors can selectively induce the expression of less than 10% of genes, some of which are involved in the inhibition of tumor growth (e.g., p21WAF1, p27Kip and p16ink4a) [19, 26, 38].
Negative_regulation (inhibition) of p21WAF1 associated with cancer
7) Confidence 0.01 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3004414 Disease Relevance 0.50 Pain Relevance 0

General Comments

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