INT97625

Context Info Confidence 0.39 First Reported 2001 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.89 Pain Relevance 0.27

signal transduction (GNRH1) extracellular space (GNRH1) extracellular region (GNRH1) cell-cell signaling (GNRH1)

Anatomy Link Frequency pituitary 2 GNRH1 (Homo sapiens)

Pain Link Frequency Relevance Heat tolerance 1 77.68 Opioid 3 68.80 antagonist 3 67.20 agonist 16 5.00 Pain 4 5.00 palliative 2 5.00 depression 1 5.00 backache 1 5.00

Disease Link Frequency Relevance Heat Prostate Cancer 43 92.00 Impaired Glucose Tolerance 1 77.68 Polycystic Ovary Syndrome 5 75.00 Obesity 3 71.64 Syndrome 2 71.20 Apoptosis 6 69.12 Cancer 10 67.68 Hyperplasia 1 51.96 Disease 8 5.00 Metastasis 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Chronic exposure to LHRH ultimately suppressed testosterone by desensitizing pituitary cells through down-regulation of the LHRH receptors (Van Loenen et al 2002).

Negative_regulation (suppressed) of Regulation (regulation) of LHRH in pituitary

1) Confidence 0.39 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504071 Disease Relevance 0.39 Pain Relevance 0

The naltrexone treatment significantly reduced the insulin response to OGTT and the LH response to GnRH bolus, whereas it did not affect the FSH and LH pulsatility patterns.

Negative_regulation (reduced) of Regulation (response) of GnRH

2) Confidence 0.36 Published 2001 Journal J. Endocrinol. Invest. Section Abstract Doc Link 11508781 Disease Relevance 0.50 Pain Relevance 0.27

General Comments

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