INT97664

Context Info Confidence 0.48 First Reported 2001 Last Reported 2001 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0.51

oxidoreductase activity (AKR1C2) cytoplasm (AKR1C2)

AKR1C2 (Homo sapiens)

Pain Link Frequency Relevance Heat fluoxetine 2 95.68 Central nervous system 2 93.88 Bile 6 88.84

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The carboxylate of ursodeoxycholate binds to AKR1C2 in the oxyanion hole at the active site.

AKR1C2 Binding (binds) of

1) Confidence 0.48 Published 2001 Journal Biochemistry Section Abstract Doc Link 11513593 Disease Relevance 0 Pain Relevance 0.25

Like other members of the superfamily, AKR1C2 folds into an alpha/beta-barrel and binds NADP(+) in an extended conformation.

AKR1C2 Binding (binds) of

2) Confidence 0.48 Published 2001 Journal Biochemistry Section Abstract Doc Link 11513593 Disease Relevance 0 Pain Relevance 0.26

General Comments

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