INT97691

Context Info Confidence 0.26 First Reported 2001 Last Reported 2001 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.09 Pain Relevance 0.23

nucleus (REST, HDAC9) transcription factor binding (REST, HDAC9) cytoplasm (REST, HDAC9) cytosol (REST) nucleolus (REST) intracellular (REST)

Anatomy Link Frequency neuronal 1 REST (Homo sapiens) HDAC9 (Homo sapiens)

Pain Link Frequency Relevance Heat sodium channel 2 96.08 Nav1.2 1 92.28 Nerve growth factor 1 83.52

Disease Link Frequency Relevance Heat Repression 1 89.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Collectively, these studies define a novel HDAC complex that is recruited by the C-terminal repressor domain of REST to actively repress genes essential to the neuronal phenotype.

REST Binding (recruited) of HDAC in neuronal

1) Confidence 0.26 Published 2001 Journal Neuron Section Abstract Doc Link 11516394 Disease Relevance 0.09 Pain Relevance 0.23

General Comments

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