INT9784

Context Info Confidence 0.47 First Reported 1985 Last Reported 2011 Negated 0 Speculated 1 Reported most in Title Documents 9 Total Number 10 Disease Relevance 6.18 Pain Relevance 1.44

extracellular region (B2M) plasma membrane (B2M)

Anatomy Link Frequency blood 1 neck 1 urine 1 body 1 B2M (Homo sapiens)

Pain Link Frequency Relevance Heat carpal tunnel syndrome 9 99.76 acular 6 90.32 methadone 1 88.04 Inflammation 2 87.28 Pain 3 86.64 anesthesia 8 75.00 addiction 1 60.40 spinal inflammation 2 50.00 imagery 27 48.28 antagonist 3 5.00

Disease Link Frequency Relevance Heat Uremia 1 100.00 Alzheimer's Dementia 18 99.98 Amyloidosis 13 99.96 Amyloid Plaque 6 99.86 Carpal Tunnel Syndrome 9 99.76 Albuminuria 4 99.40 Spontaneous Fractures 2 99.14 Bone Cysts 2 98.42 Acquired Immune Deficiency Syndrome Or Hiv Infection 11 97.88 Autosomal Dominant Polycystic Kidney 111 93.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Based on the rate of formation of beta 2-microglobulin in the body and the mode of transmission and mass transfer resistance of solute, the concept of week clearance index of beta 2-microglobulin (R value) was suggested.

beta 2-microglobulin Binding (formation) of in body

1) Confidence 0.47 Published 1996 Journal Zhonghua Nei Ke Za Zhi Section Abstract Doc Link 9387629 Disease Relevance 0.13 Pain Relevance 0.07

Pathological fractures and lytic bone lesion of the femoral neck associated with beta 2-microglobulin amyloid deposition in long-term dialysis patients.

beta 2-microglobulin Binding (associated) of in neck associated with alzheimer's dementia and spontaneous fractures

2) Confidence 0.36 Published 1991 Journal Arch Orthop Trauma Surg Section Title Doc Link 2015141 Disease Relevance 0.70 Pain Relevance 0.32

Histochemical and immunohistochemical characterization of amyloid associated with chronic hemodialysis as beta 2-microglobulin.

2-microglobulin Binding (associated) of associated with alzheimer's dementia

3) Confidence 0.32 Published 1985 Journal Lab. Invest. Section Title Doc Link 2415776 Disease Relevance 0.81 Pain Relevance 0.10

Ten of the 11 biopsied bone cysts in 8 patients with carpal tunnel syndrome demonstrated amyloid deposits which reacted with B2M.

B2M Binding (reacted) of associated with carpal tunnel syndrome, amyloid plaque and bone cysts

4) Confidence 0.31 Published 1992 Journal Nephron Section Abstract Doc Link 1436294 Disease Relevance 1.07 Pain Relevance 0.27

Beta 2-microglobulin associated amyloidosis: a vanishing complication of long-term hemodialysis?

Beta 2-microglobulin Binding (associated) of associated with amyloidosis

5) Confidence 0.31 Published 1997 Journal Kidney Int. Section Title Doc Link 9328948 Disease Relevance 0.52 Pain Relevance 0.07

A new type of amyloidosis, predominantly osteoarticular, has recently been recognized in uremic patients on hemodialysis, beta 2-microglobulin being the major constituent protein.

beta 2-microglobulin Binding (recognized) of associated with amyloidosis and uremia

6) Confidence 0.28 Published 1990 Journal Am. J. Nephrol. Section Abstract Doc Link 2080789 Disease Relevance 0.85 Pain Relevance 0.06

In addition, B2M and H-FABP were associated inversely with measured GFR and effective renal blood flow independent of albuminuria; KIM-1, NGAL, and MCP-1 were associated positively with total renal volume independent of albuminuria [54].

B2M Binding (associated) of in blood associated with albuminuria

7) Confidence 0.25 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3017903 Disease Relevance 0.81 Pain Relevance 0.07

METHODS: Human cell transfectants expressing or lacking the transporter associated with antigen processing were used to determine the cell surface expression of B27 subtypes by flow cytometry with antibodies recognizing the B27 heterodimer or beta2-microglobulin (beta2m)-free heavy chains.

beta2-microglobulin Binding (recognizing) of

8) Confidence 0.07 Published 2005 Journal Arthritis Rheum. Section Body Doc Link 16200602 Disease Relevance 0.18 Pain Relevance 0

Relationship of beta 2 microglobulin and CD4 counts to neuropsychological performance in HIV-1-infected intravenous drug users.

beta 2 microglobulin Binding (Relationship) of associated with acquired immune deficiency syndrome or hiv infection

9) Confidence 0.04 Published 1994 Journal J. Acquir. Immune Defic. Syndr. Section Title Doc Link 7916050 Disease Relevance 0.96 Pain Relevance 0.09

We assessed this possible interaction using urine N-acetyl-beta-D-glucosaminidase indexed to urinary creatinine (U-NAG/crea) as a marker of proximal tubular, beta2-microglobulin as a tubular, urine oxygen tension (P(u)O(2)) as a medullary, and erythropoietin as a marker of tubulointerstitial damage.

beta2-microglobulin Spec (possible) Binding (interaction) of in urine

10) Confidence 0.01 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11273951 Disease Relevance 0.15 Pain Relevance 0.39

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