INT97861

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Context Info
Confidence 0.13
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.11
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CTSA) mitochondrion (CTSA) small molecule metabolic process (CTSA)
endoplasmic reticulum (CTSA) nucleolus (CTSA) nucleus (CTSA)
Anatomy Link Frequency
B lymphocytes 2
CTSA (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 1 89.04 High High
imagery 3 49.96 Quite Low
peripheral neuropathy 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Paresthesia 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
antidepressant 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 41 99.40 Very High Very High Very High
Death 6 85.68 High High
Pick Disease Of The Brain 3 75.00 Quite High
Gangliosidoses 1 74.80 Quite High
Congenital Anomalies 2 72.04 Quite High
Neurologic Manifestations 17 62.12 Quite High
Virus Diseases 1 59.52 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 57.68 Quite High
Gauchers Disease 40 55.72 Quite High
Paralysis 2 53.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several animal studies also showed that depletion of GSL could be lethal or lead to neurological disturbance, and substrate reduction therapy should be aimed to reduce biosynthesis of GSL to a degree that can be tolerated by cells (Radin 1996).
Negative_regulation (reduce) of Gene_expression (biosynthesis) of GSL
1) Confidence 0.13 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504062 Disease Relevance 0.31 Pain Relevance 0
These results are consistent with our hypothesis and with GSLs being centrally involved in the pathogenesis of NPC disease, and they suggest that drugs inhibiting GSL synthesis could have a similar ameliorating effect on the human disorder.
Negative_regulation (inhibiting) of Gene_expression (synthesis) of GSL associated with disease
2) Confidence 0.06 Published 2001 Journal Curr. Biol. Section Abstract Doc Link 11525744 Disease Relevance 0.50 Pain Relevance 0.09
The inhibition of GSL synthesis by miglustat has been demonstrated to reduce pathological intracellular lipid storage, improve fluid-phase endosomal uptake and normalize lipid transport in peripheral blood B lymphocytes of NP-C patients.44 This leads to a reduction of the potentially neurotoxic accumulation of gangliosides GM2 and GM3, lactosylceramide and glucosylceramide, and may prevent further neuronal damage.
Negative_regulation (inhibition) of Gene_expression (synthesis) of GSL in B lymphocytes
3) Confidence 0.03 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2781062 Disease Relevance 0.30 Pain Relevance 0

General Comments

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