INT97878

Context Info Confidence 0.50 First Reported 2001 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 6 Total Number 6 Disease Relevance 2.73 Pain Relevance 4.65

nucleus (Pias1) enzyme binding (Pias1) DNA binding (Pias1) ligase activity (Pias1)

Anatomy Link Frequency plasma 1 brain 1 Pias1 (Mus musculus)

Pain Link Frequency Relevance Heat Gabapentin 50 100.00 anticonvulsant 2 96.80 Inflammation 88 96.56 Neuropathic pain 2 92.88 cerebral cortex 1 91.08 antagonist 2 83.60 carbamazepine 1 68.96 antiepileptic Drug 1 67.48 agonist 17 63.60 cytokine 37 57.64

Disease Link Frequency Relevance Heat Convulsion 6 98.84 Cognitive Disorder 4 97.52 INFLAMMATION 105 96.56 Syndrome 2 93.28 Neuropathic Pain 2 92.88 Neurodegenerative Disease 2 87.04 Disease 14 83.76 Targeted Disruption 13 82.00 Epilepsy 1 75.00 Cardiovascular Disease 18 51.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

There is evidence, however, that the neuroprotective properties attributed to GBP are rather associated with a derivative of GBP, gabapentin-lactam (GBP-L), which opens mitochondrial ATP-dependent K+ channels, in contrast to GBP.

Positive_regulation (derivative) of GBP associated with gabapentin

1) Confidence 0.50 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15322735 Disease Relevance 0.58 Pain Relevance 1.41

There is evidence, however, that the neuroprotective properties attributed to GBP are rather associated with a derivative of GBP, gabapentin-lactam (GBP-L), which opens mitochondrial ATP-dependent K+ channels, in contrast to GBP.

Positive_regulation (derivative) of GBP-L associated with gabapentin

2) Confidence 0.50 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15322735 Disease Relevance 0.59 Pain Relevance 1.43

These results suggest that maintenance of stable GBP plasma levels could protect against seizures without causing memory impairment.

Positive_regulation (maintenance) of GBP in plasma associated with cognitive disorder, convulsion and gabapentin

3) Confidence 0.41 Published 2010 Journal Epilepsy Behav Section Abstract Doc Link 20079694 Disease Relevance 0.45 Pain Relevance 0.82

AEDs either increased (PHT and GBP) or decreased (SVP) brain histamine content in different regions to varying degrees.

Positive_regulation (increased) of GBP in brain associated with gabapentin

4) Confidence 0.26 Published 2001 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11526971 Disease Relevance 0.40 Pain Relevance 0.63

interacts with the protein inhibitor of the activated transcription factor, STAT-1 (PIAS1).

Positive_regulation (activated) of PIAS1

5) Confidence 0.24 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.23 Pain Relevance 0.14

associates with the protein inhibitor of activated STAT1 (PIAS1), which is a small ubiquitin-like modifier (SUMO)-E3 ligase, in a ligand-dependent manner.

Positive_regulation (activated) of PIAS1

6) Confidence 0.18 Published 2010 Journal PPAR Research Section Body Doc Link PMC2931381 Disease Relevance 0.48 Pain Relevance 0.21

General Comments

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