INT97979

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Context Info
Confidence 0.02
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.06
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 1
T-lymphocyte 1
Hrec (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 286 100.00 Very High Very High Very High
chemokine 16 100.00 Very High Very High Very High
Inflammation 112 97.40 Very High Very High Very High
agonist 12 83.04 Quite High
Pain 2 54.40 Quite High
addiction 4 8.08 Low Low
Inflammatory response 14 5.00 Very Low Very Low Very Low
antagonist 11 5.00 Very Low Very Low Very Low
tolerance 10 5.00 Very Low Very Low Very Low
rheumatoid arthritis 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Plasmodium Infection 34 99.68 Very High Very High Very High
Targeted Disruption 11 99.64 Very High Very High Very High
Disease 61 99.58 Very High Very High Very High
Infection 71 99.36 Very High Very High Very High
INFLAMMATION 130 97.40 Very High Very High Very High
Sprains And Strains 58 97.36 Very High Very High Very High
Autoimmune Disease 25 97.00 Very High Very High Very High
Asthma 41 95.36 Very High Very High Very High
Immunization 40 94.00 High High
Necrosis 4 92.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
can be the mediator of the up-regulation of chemokines and cytokines during malaria infection, which is independent of TLRs but dependent on MyD88 [46].
Regulation (regulation) of cytokines associated with chemokine, plasmodium infection, infection and cytokine
1) Confidence 0.02 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.86 Pain Relevance 0.30
It is possible that macrophages, NK, and CD8 cells are responsible for the increased levels of TH1 cytokines observed in this study, which would agree with other murine models [21, 30, 38, 39].
Regulation (responsible) of cytokines in macrophages associated with cytokine
2) Confidence 0.02 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2852613 Disease Relevance 0.86 Pain Relevance 0.05
between Th1 and Th2, and suppressive effect on excessive Th2 cytokines.
Regulation (effect) of cytokines associated with cytokine
3) Confidence 0.02 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.86 Pain Relevance 0.34
Not surprisingly, it was not sufficient to provide full protection likely due to the complexity of malarial disease, which is under the regulation of many different receptors, cytokines, signaling events and physiological features.
Regulation (regulation) of cytokines associated with disease and cytokine
4) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.96 Pain Relevance 0.26
It also modulates Con-A-induced cytokines when administered in vivo four hours before Con-A in vitro stimulation, a situation in which its effect could be mediated by its activity on other cell types.
Regulation (modulates) of cytokines associated with cytokine
5) Confidence 0.01 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.21 Pain Relevance 0.31
Our present findings showing the modulation of T-lymphocyte cytokines indicates that the PROK system is involved in modulating both innate and acquired immunity.
Regulation (modulation) of cytokines in T-lymphocyte associated with cytokine
6) Confidence 0.01 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.18 Pain Relevance 0.35
The Bv8-induced effects were lost in mice lacking the PROKR 1 gene, thus indicating that PROKR 1 is the receptor involved in the modulation of cytokines.


Regulation (modulation) of cytokines associated with cytokine
7) Confidence 0.01 Published 2008 Journal BMC Immunol Section Abstract Doc Link PMC2584092 Disease Relevance 0.23 Pain Relevance 0.31
Panels A and B in Figure 3 show the concentrations of the Th1 cytokines, IL-2 and IFN-?
Regulation (concentrations) of cytokines associated with cytokine
8) Confidence 0.01 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0 Pain Relevance 0.09
Down regulation of Th1 cytokines in IL-5 transgenic mice is unclear
Regulation (n regulati) of cytokines associated with targeted disruption and cytokine
9) Confidence 0.00 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2933908 Disease Relevance 0.72 Pain Relevance 0.05
Most results from ground-based studies in rodents indicate either no alterations in cytokines or decreased levels.
Neg (no) Regulation (alterations) of cytokines associated with cytokine
10) Confidence 0.00 Published 1995 Journal J Gravit Physiol Section Abstract Doc Link 11538892 Disease Relevance 0.18 Pain Relevance 0.34

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