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Context Info
Confidence 0.42
First Reported 2001
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 20.57
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (FAS) protein complex assembly (FAS) cytoplasm (FAS)
signal transducer activity (FAS) cytosol (FAS) signal transduction (FAS)
Anatomy Link Frequency
plasma 4
liver 2
glandular epithelial cells 1
T cells 1
FAS (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 112 99.44 Very High Very High Very High
Morphine 9 98.98 Very High Very High Very High
chemokine 3 93.24 High High
rheumatoid arthritis 75 86.92 High High
Inflammation 149 86.52 High High
cINOD 9 73.28 Quite High
Inflammatory mediators 13 54.64 Quite High
COX2 4 35.44 Quite Low
agonist 3 33.44 Quite Low
Arthritis 65 23.24 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 546 100.00 Very High Very High Very High
Death 66 100.00 Very High Very High Very High
Cancer 105 99.76 Very High Very High Very High
Necrosis 23 99.52 Very High Very High Very High
Acute Renal Failure 332 99.44 Very High Very High Very High
Hepatitis 3 99.30 Very High Very High Very High
Burns 300 99.22 Very High Very High Very High
Chorioamnionitis 66 99.04 Very High Very High Very High
Injury 72 98.64 Very High Very High Very High
Coronary Artery Disease 45 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No significant changes in the levels of CD4, CD8, CD95 was observed in the co-culture conditions tested.
Neg (No) Regulation (changes) of CD95
1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.09 Pain Relevance 0
Here, we show that burns septic ARF group plasma induced both activation of caspases and up-regulation of Fas on tubular cells.
Regulation (regulation) of Fas in plasma associated with acute renal failure and burns
2) Confidence 0.37 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 2.66 Pain Relevance 0.11
The Fas/CD95 was down regulated 2 fold in the cells expanded in presence of zVADfmk, and was reduced 2.75 times in the cultures expanded in the presence of zLLYfmk.
Regulation (regulated) of Fas
3) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923186 Disease Relevance 0.29 Pain Relevance 0
However, it is still not fully understood what causes the up-regulation of FasL/Fas on keratinocytes, and how the immune system, including T cells found in blister fluid at the onset of disease may regulate this.
Regulation (regulation) of Fas in T cells associated with blister and disease
4) Confidence 0.26 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.49 Pain Relevance 0.05
In a mouse model of fulminant hepatitis, intravenous application of siRNA targeting the death receptor CD95 (APO-1/Fas) was capable of preventing liver injury [57].
Regulation (targeting) of CD95 in liver associated with injury, death and hepatitis
5) Confidence 0.26 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.86 Pain Relevance 0
In a mouse model of fulminant hepatitis, intravenous application of siRNA targeting the death receptor CD95 (APO-1/Fas) was capable of preventing liver injury [57].
Regulation (targeting) of Fas in liver associated with injury, death and hepatitis
6) Confidence 0.26 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.86 Pain Relevance 0
In addition, some specific membrane FAs are strongly altered by diet, and such alterations have been shown to reduce risk for CHD [38], [39].
Regulation (altered) of FAs associated with coronary artery disease
7) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2673680 Disease Relevance 0.97 Pain Relevance 0.08
Gene array analysis demonstrated that burns septic ARF group plasma induced an up-regulation of several pro-apoptotic genes such as Fas, Fas-Ligand (Fas-L), Bax and Bak and of positive regulators of apoptosis (Abl1, Gadd45a).
Regulation (regulation) of Fas-L in plasma associated with acute renal failure, burns and apoptosis
8) Confidence 0.22 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.57 Pain Relevance 0.07
Gene array analysis demonstrated that burns septic ARF group plasma induced an up-regulation of several pro-apoptotic genes such as Fas, Fas-Ligand (Fas-L), Bax and Bak and of positive regulators of apoptosis (Abl1, Gadd45a).
Regulation (regulation) of Fas in plasma associated with acute renal failure, burns and apoptosis
9) Confidence 0.22 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.57 Pain Relevance 0.06
Gene array analysis demonstrated that burns septic ARF group plasma induced an up-regulation of several pro-apoptotic genes such as Fas, Fas-Ligand (Fas-L), Bax and Bak and of positive regulators of apoptosis (Abl1, Gadd45a).
Regulation (regulation) of Fas in plasma associated with acute renal failure, burns and apoptosis
10) Confidence 0.22 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.56 Pain Relevance 0.06
These levels reflect a mixture of diet and metabolism since the essential FAs (omega-3 and omega-6) are strongly affected by diet whereas palmitic and stearic, which can be synthesized de novo, reflect metabolic processes.
Regulation (affected) of FAs
11) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2673680 Disease Relevance 0.32 Pain Relevance 0
Therefore, we analyzed whether the ability of morphine to affect Th2 cytokine production was mediated by regulation of Fas, FasL, and TRAIL expression and AICD directly in purified Th cells.
Spec (whether) Regulation (regulation) of Fas associated with death, cytokine and morphine
12) Confidence 0.22 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16210602 Disease Relevance 0.69 Pain Relevance 0.86
Sulindac sulfide specifically up-regulated the DR5 levels but had no effect on the levels of other DRs including DR4, Fas, and tumor necrosis factor receptor 1.
Neg (no) Regulation (effect) of Fas associated with necrosis and cancer
13) Confidence 0.18 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11559570 Disease Relevance 1.69 Pain Relevance 0.07
causes destruction of acini by up-regulation of Fas at the surface of the glandular epithelial cells, stimulation of secretion of type 2 and 9 matrix metalloproteases by epithelial cells, and overexpression of different chemokines [3–5].
Regulation (regulation) of Fas in glandular epithelial cells associated with chemokine
14) Confidence 0.14 Published 2007 Journal Clin Rev Allergy Immunol Section Body Doc Link PMC2071970 Disease Relevance 1.08 Pain Relevance 0.13
-mediated inhibition of TRAIL-signaling could not be accounted for by significant changes in TRAIL-R, procaspases-3,-8,-9, Fas-activated death domain protein (FADD), tumor necrosis factor receptor 1-associated death domain protein, silencer of death domain protein, FADD-like-interleukin-1?
Regulation (changes) of Fas associated with necrosis, cancer and death
15) Confidence 0.12 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 1.75 Pain Relevance 0.31
In fact, autoimmune lymphoproliferative syndrome (ALPS), MS, type 1 diabetes and multiple autoimmune syndrome, have been linked to decreased Fas functionality [68] and, as discussed previously, antioxidants may up-regulate Fas and FasL in vitro.
Spec (may) Regulation (regulate) of Fas associated with syndrome, diabetes mellitus and autoimmune lymphoproliferative syndrome
16) Confidence 0.10 Published 2008 Journal Nutr J Section Body Doc Link PMC2572622 Disease Relevance 1.74 Pain Relevance 0.26
In conclusion, the frequency differences in this study highlight the significance and biological relevance of genetic factors, IL-10, MBL and Fas regulation among women with acute chorioamnionitis and adverse pregnancy outcome.


Regulation (regulation) of Fas associated with chorioamnionitis
17) Confidence 0.10 Published 2005 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC554771 Disease Relevance 0.36 Pain Relevance 0
Affymetrix microarray analysis of gene expression profiles revealed that butyrate treatment down-regulated pro-apoptotic BAD, BAX and BAK, genes associated with the mitochondrial pathway, while genes associated with the death receptor pathway, such as Fas, FasL, Trail and DR5, were basically not affected by the treatment (data not shown).
Regulation (affected) of Fas associated with apoptosis and death
18) Confidence 0.09 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.92 Pain Relevance 0

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