INT9818

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Context Info
Confidence 0.34
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 0.67
Pain Relevance 6.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Pdia4) endoplasmic reticulum (Pdia4)
Anatomy Link Frequency
myocytes 2
cardiomyocytes 1
vesicle 1
body 1
Pdia4 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 33 99.98 Very High Very High Very High
Glutamate 1 99.76 Very High Very High Very High
Enkephalin 19 99.66 Very High Very High Very High
Kappa opioid receptor 12 99.16 Very High Very High Very High
agonist 13 98.98 Very High Very High Very High
opioid receptor 4 98.82 Very High Very High Very High
nMDA receptor 4 98.46 Very High Very High Very High
narcan 12 97.16 Very High Very High Very High
Opioid 5 94.64 High High
antagonist 8 94.40 High High
Disease Link Frequency Relevance Heat
Myositis 42 98.66 Very High Very High Very High
Death 3 92.56 High High
Stress 28 69.12 Quite High
Disease 6 65.16 Quite High
Targeted Disruption 1 48.56 Quite Low
INFLAMMATION 29 33.68 Quite Low
Autoimmune Disease 1 31.76 Quite Low
Muscle Weakness 4 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Disorders Of Creatine Metabolism 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NMDA receptor-mediated responses were determined by measurement of L-glutamate-stimulated increases in free intracellular calcium concentration (Cai) using the fluorescent indicator for Cai, Indo 1, in microsacs (a cell-free brain membrane vesicle preparation) isolated from hippocampi or cerebral cortices of the two mouse lines.
Positive_regulation (increases) of Cai in vesicle associated with glutamate and nmda receptor
1) Confidence 0.34 Published 1994 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 7695048 Disease Relevance 0 Pain Relevance 0.27
It was found that both morphine at 100-250 microM and DAGO at 23-75 microM increased Cai dose-dependently and that the effect was significantly antagonized by naloxone at a concentration of 50 microM, which itself did not cause any significant alteration in Cai.
Positive_regulation (increased) of Cai associated with narcan, enkephalin and morphine
2) Confidence 0.23 Published 1991 Journal Life Sci. Section Abstract Doc Link 1847734 Disease Relevance 0 Pain Relevance 1.48
The results suggest that morphine increases Cai by directly activating the cardiac receptors (most likely micro-receptors) on the membrane of ventricular myocytes.
Positive_regulation (increases) of Cai in myocytes associated with morphine
3) Confidence 0.17 Published 1991 Journal Life Sci. Section Abstract Doc Link 1847734 Disease Relevance 0 Pain Relevance 1.38
Pretreatment with morphine also abolished the morphine-induced increase in Cai of isolated myocytes.
Positive_regulation (increase) of Cai in myocytes associated with morphine
4) Confidence 0.15 Published 1991 Journal Life Sci. Section Abstract Doc Link 1847734 Disease Relevance 0 Pain Relevance 1.42
Except for sporadic inclusion-body myositis, where the ER chaperones calnexin, calreticulin, Grp78, Grp94 and ERp72 are upregulated and colocalize with intracellular aggregates [11,12], the present knowledge about changes in ER chaperone level and distribution among myofibers of myositis patients is far from complete.
Positive_regulation (upregulated) of ERp72 in body associated with myositis
5) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.67 Pain Relevance 0
In rat ventricular cardiomyocytes loaded with the fluorescent Ca2+ indicator Indo-1/AM, the delta opioid receptor agonist Leu-Enk caused Cai oscillations and abolished the caffeine-induced Cai transient.
Positive_regulation (caffeine-induced) of Cai in cardiomyocytes associated with agonist and opioid receptor
6) Confidence 0.05 Published 1991 Journal Boll. Soc. Ital. Biol. Sper. Section Abstract Doc Link 1657046 Disease Relevance 0 Pain Relevance 0.48
Stimulation with the muscarinic agonist carbachol (100 microM) caused a clearly biphasic intracellular calcium (Cai) response: Cai was stimulated from resting levels (85 +/- 3 nM, n = 100) to a sudden transient peak (821 +/- 44 nM) followed by a sustained plateau (317 +/- 12 nM).
Positive_regulation (stimulated) of Cai associated with agonist
7) Confidence 0.05 Published 1992 Journal Pflugers Arch. Section Abstract Doc Link 1437524 Disease Relevance 0 Pain Relevance 0.12
The initial Cai increase often was followed by Cai oscillations.
Positive_regulation (increase) of Cai
8) Confidence 0.03 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1659231 Disease Relevance 0 Pain Relevance 0.36
The amplitude of contraction that accompanied the Cai increase elicited by U-50488H was greater than that associated with a similar increase in Cai elicited by electrical stimulation or by the rapid exposure of cells to caffeine.
Positive_regulation (increase) of Cai
9) Confidence 0.03 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1659231 Disease Relevance 0 Pain Relevance 0.39
Thus an acute and brief kappa-opioid receptor stimulation of cardiac cells leads to an increase in Cai and pHi.
Positive_regulation (increase) of Cai associated with kappa opioid receptor
10) Confidence 0.03 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1659231 Disease Relevance 0 Pain Relevance 0.37
The amplitude of contraction that accompanied the Cai increase elicited by U-50488H was greater than that associated with a similar increase in Cai elicited by electrical stimulation or by the rapid exposure of cells to caffeine.
Positive_regulation (increase) of Cai
11) Confidence 0.03 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1659231 Disease Relevance 0 Pain Relevance 0.39
The results indicate that Cl- are the primary charge carriers for this current and that Cai2+ is required for its activation, leading us to identify it as ICl(Ca).
Positive_regulation (required) of Cai2
12) Confidence 0.02 Published 1986 Journal J. Neurophysiol. Section Abstract Doc Link 2426420 Disease Relevance 0 Pain Relevance 0

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